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NCT00263120 · ClinicalTrials.gov registry record
Effects of Thymectomy During Cardiothoracic Surgery
A clinical trial of Thymectomy and Cardiothoracic Surgery, sponsored by University of California, Los Angeles.
- Completed
- Registry status
- 124
- Enrollment target
- 1
- Study location
NCT00263120: Completed study of Thymectomy and Cardiothoracic Surgery, sponsored by University of California, Los Angeles.
NCT00263120 is a study of Thymectomy and Cardiothoracic Surgery that has completed, run by University of California, Los Angeles. The registered enrollment target is 124 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00263120, a study of Thymectomy and Cardiothoracic Surgery, has completed, sponsored by University of California, Los Angeles.
- COMPLETED
- Registry status
- 124 participants
- Enrollment target
- 1
- Study location
Study Summary
The thymus is known to be the site of T cell development in humans. Due to its location in the chest in front of the heart, incidental thymecomy is commonly performed during cardiothoracic surgery, especially in infants and children, so that surgeons may gain access to the surgical field. This practice has been considered safe because it was thought that the thymus is inactive after birth. However, recent data using newly developed techniques has demonstrated that the thymus normally is active well into adulthood. In addition, in a previous study (UCLA IRB # 02-03-008-02) we have demonstrated alterations in lymphocyte (T cells) number in individuals who have undergone thymectomy in childhood but we do not know how immunity is affected. We plan to investigate if immune development or immune function later in life is affected by the loss of T cell production caused by thymectomy during cardiothoracic surgical procedures in childhood. At UCLA, a large number of patients are seen who have congenital heart disease and undergo surgical procedures for correction or repair and many children and adults are followed for many years after they have undergone surgical procedures. Subjects for study will be recruited from among these patients. We propose a study which will examine the number and activity of lymphocytes obtained from blood samples from child and young adult subjects who have undergone surgery in early childhood. We will determine if these subjects have had complete thymectomy in the past using CT or MRI (obtained during routine care) or, for subjects who are having cardiothoracic surgery, by visualization of thymic tissue during the procedure. In addition we will give vaccination for a common viral illness (hepatitis A) and measure immune responses to it (from a blood sample). As part of this study, we will ask for medical information consisting of a history of congenital cardiac disease and other diagnoses (such as asthma), a history of infections and hospitaliz
Conditions Studied
Interventions
- BEHAVIORAL Pain Questionnaire
Study Locations (1)
California
- UCLA Adult Congenital Heart Disease Clinic - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 124 participants |
| Start Date | 2006-03 |
| Est. Completion | 2010-03 |
What the finished NCT00263120 record still lists
NCT00263120 is an observational study that tracks outcomes without assigning an intervention. The registered 124 participants enrollment target is mid-sized for trials with a published cap.
The record links to 1 condition, with Thymectomy and Cardiothoracic Surgery appearing as the primary indexed condition, and to 1 intervention - of which Pain Questionnaire is the first listed.
NCT00263120 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT00263120 about?
NCT00263120 is a clinical study titled "Effects of Thymectomy During Cardiothoracic Surgery". The thymus is known to be the site of T cell development in humans. Due to its location in the chest in front of the heart, incidental thymecomy is commonly performed during cardiothoracic surgery, especially in infants and children, so that surgeons may gain access to the surgical field. This pract...
What is the current status of trial NCT00263120?
This trial is currently completed. The enrollment target is 124 participants. The study started on 2006-03. Estimated completion is 2010-03.
What conditions does trial NCT00263120 study?
This clinical trial studies the following conditions: Thymectomy and Cardiothoracic Surgery.
What interventions are being tested in trial NCT00263120?
The interventions under investigation include: Pain Questionnaire (BEHAVIORAL).
Who is sponsoring clinical trial NCT00263120?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00263120 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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