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NCT00250133 · ClinicalTrials.gov registry record
Microbiologic Effect of Selective Decontamination of the Digestive Tract With Colistin, Gentamicin and Nystatin
A clinical trial, sponsored by University of Pittsburgh.
- Terminated
- Registry status
- 40
- Enrollment target
NCT00250133: Clinical Trial study, sponsored by University of Pittsburgh.
NCT00250133 is a clinical trial that was terminated before completion, run by University of Pittsburgh. The registered enrollment target is 40 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00250133 was terminated before completion, sponsored by University of Pittsburgh.
- TERMINATED
- Registry status
- 40 participants
- Enrollment target
Study Summary
Selective decontamination of the digestive tract (SDD) is a prophylactic measure aimed at reducing Gram negative flora in the gut with an aim to reduce nosocomial infections such as ventilator-associated pneumonia. A recent large randomized trial in the Netherlands showed that SDD use was associated with reduced mortality in the ICU. Theoretically, SDD may select for Gram positive organisms such as MRSA or VRE. This was not observed in the Dutch study, but the rates of MRSA and VRE are very low in hospitals in the Netherlands. Fears of selection of MRSA and VRE have limited application of SDD in the United States. In this pilot study, 40 patients in the transplant intensive care unit (where SDD has been used intermittently for at least 10 years), will be randomized to SDD or no SDD. These patients will be known to be VRE positive at baseline. The effects of SDD on the density of VRE in the stool on day 7 compared to pre-SDD will be the primary endpoint. Secondary endpoints will be detection of MRSA and colistin resistant Pseudomonas in the stool.
Interventions
- PROCEDURE Blood draws
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
Why NCT00250133 stopped before completion
NCT00250133 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Blood draws is the first listed.
NCT00250133 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00250133 about?
NCT00250133 is a clinical study titled "Microbiologic Effect of Selective Decontamination of the Digestive Tract With Colistin, Gentamicin and Nystatin". Selective decontamination of the digestive tract (SDD) is a prophylactic measure aimed at reducing Gram negative flora in the gut with an aim to reduce nosocomial infections such as ventilator-associated pneumonia. A recent large randomized trial in the Netherlands showed that SDD use was associated...
What is the current status of trial NCT00250133?
This trial is currently terminated. The enrollment target is 40 participants.
What interventions are being tested in trial NCT00250133?
The interventions under investigation include: Blood draws (PROCEDURE).
Who is sponsoring clinical trial NCT00250133?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
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