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NCT00245830 · ClinicalTrials.gov registry record · NA
Ischemic Preconditioning of Liver in Cadaver Donors
A NA study, sponsored by University of Medicine and Dentistry of New Jersey.
- Completed
- Registry status
- NA
- Development phase
- 100
- Enrollment target
NCT00245830 is a NA study that has completed, run by University of Medicine and Dentistry of New Jersey. The registered enrollment target is 100 participants.
The verdict
NCT00245830, a NA study, has completed, sponsored by University of Medicine and Dentistry of New Jersey.
- COMPLETED
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
Study Summary
The long-term goals of this proposal are to develop clinical protocols of donor preconditioning to improve liver graft function and ameliorate complications of poor graft function after liver transplantation. Achievement of these objectives would improve liver recipient outcomes, increase utilization of livers and alleviate the current critical shortage of livers for transplantation. More stringent liver donor selection intended to decrease the complications of poor graft function conflicts directly with efforts to maximize the use of donor livers. Ischemic preconditioning (IPC) of liver attenuates hepatic ischemia reperfusion injury (IRI) in animals. Preliminary data show hepatic IPC effectively decreases IRI following hepatic resection in humans. The specific aims of this project are: AIM 1: To test the hypothesis that 10 minutes of hepatic ischemic preconditioning in deceased donors would improve liver graft function and decrease injury in the early post transplant period. AIM 2: To test the hypothesis that ischemic preconditioning of deceased donor livers would decrease systemic inflammatory response in liver recipients in the early post transplant period. AIM 3: To examine whether ischemic preconditioning of deceased donor livers decreases early post transplant pulmonary edema and acute rejection and shortens hospital stay.
Interventions
- PROCEDURE Ischemic Preconditioning
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2003-10 |
| Est. Completion | 2007-03 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00245830
The ClinicalTrials.gov registry entry for NCT00245830 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Medicine and Dentistry of New Jersey, which has 88 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Ischemic Preconditioning is the first listed.
NCT00245830 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00245830 about?
NCT00245830 is a clinical study titled "Ischemic Preconditioning of Liver in Cadaver Donors". The long-term goals of this proposal are to develop clinical protocols of donor preconditioning to improve liver graft function and ameliorate complications of poor graft function after liver transplantation. Achievement of these objectives would improve liver recipient outcomes, increase utilizatio...
What is the current status of trial NCT00245830?
This trial is currently completed. It is a NA study. The enrollment target is 100 participants. The study started on 2003-10. Estimated completion is 2007-03.
What interventions are being tested in trial NCT00245830?
The interventions under investigation include: Ischemic Preconditioning (PROCEDURE).
Who is sponsoring clinical trial NCT00245830?
This trial is sponsored by University of Medicine and Dentistry of New Jersey, which has 88 total clinical trials registered on ClinicalTrials.gov.
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