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NCT00235664 · ClinicalTrials.gov registry record
Prospective Study of Drug Resistant Pathogens Among Liver, Intestinal and Multivisceral Transplant Recipients
A clinical trial, sponsored by University of Pittsburgh.
- Completed
- Registry status
- 200
- Enrollment target
NCT00235664 is a clinical trial that has completed, run by University of Pittsburgh. The registered enrollment target is 200 participants.
The verdict
NCT00235664 has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- 200 participants
- Enrollment target
Study Summary
Infections caused by multidrug resistant bacteria have become more prevalent at many tertiary care and academic centers. These infections are associated with increased morbidity and mortality. The initial empiric antibiotic choice may not be adequate and delay in initiating appropriate therapy is a reason for poorer outcomes. Furthermore, not uncommonly the only therapeutic options available are associated with significant toxicity. This is a particular challenge for solid organ transplant recipients, who are immunosuppressed and have a higher risk of acquiring infections. Exposure to different classes of antibiotics has been linked to development of antibiotic resistance. Determining the risk factors for acquisition of drug-resistant bacteria and the molecular mechanisms by which resistance occurs would allow the development and implementation of strategies to minimize these infections and therefore improve outcomes. We, the researchers at the University of Pittsburgh, aim to collect surveillance cultures on patients undergoing liver, intestinal and multivisceral transplantation in order to determine the prevalence and risk factors for Pseudomonas aeruginosa (P. aeruginosa), extended-spectrum β-lactamases (ESBL)-Klebsiella and methicillin-resistant Staphylococcus aureus (MRSA), as well as determine the molecular mechanisms associated with the development of resistance in P. aeruginosa.
Interventions
- PROCEDURE Collection of stool and endotracheal aspirate samples
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2005-10 |
| Est. Completion | 2007-12 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00235664
The ClinicalTrials.gov registry entry for NCT00235664 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Pittsburgh, which has 1,238 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Collection of stool and endotracheal aspirate samples is the first listed.
NCT00235664 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00235664 about?
NCT00235664 is a clinical study titled "Prospective Study of Drug Resistant Pathogens Among Liver, Intestinal and Multivisceral Transplant Recipients". Infections caused by multidrug resistant bacteria have become more prevalent at many tertiary care and academic centers. These infections are associated with increased morbidity and mortality. The initial empiric antibiotic choice may not be adequate and delay in initiating appropriate therapy is a ...
What is the current status of trial NCT00235664?
This trial is currently completed. The enrollment target is 200 participants. The study started on 2005-10. Estimated completion is 2007-12.
What interventions are being tested in trial NCT00235664?
The interventions under investigation include: Collection of stool and endotracheal aspirate samples (PROCEDURE).
Who is sponsoring clinical trial NCT00235664?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
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