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NCT00232817 · ClinicalTrials.gov registry record · Phase 4
Anesthesia and Postoperative Pain
A Phase 4 study, sponsored by Columbia University.
- Completed
- Registry status
- Phase 4
- Development phase
- 23
- Enrollment target
NCT00232817: Completed Phase 4 study, sponsored by Columbia University.
NCT00232817 is a Phase 4 study that has completed, run by Columbia University. The registered enrollment target is 23 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00232817, a Phase 4 study, has completed, sponsored by Columbia University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 23 participants
- Enrollment target
Study Summary
The purpose of this study is to compare post-operative pain after anesthesia with either isoflurane or propofol. Each group will be further randomized to receive intranasal nicotine or placebo in order to detect potential pronociceptive action of isoflurane. The study is a randomized, prospective, double-blinded controlled trial. Eighty adult women undergoing uterine surgery will be recruited for this study. Enrollment in this study is limited to women, because the animal studies suggest that females have a greater hyperalgesic response to volatile anesthetics than do males. The patient will be given one of two standard anesthetics for their surgery: isoflurane or propofol. The investigators are interested in these two anesthetics because we seek to see if there exists a difference in their effects on a patient's perception of pain, as has been shown to be the case in animal studies but has not yet been studied in humans.
Primary Outcome
Pain was reported on the Numerical Rating Scale for pain (NRS) with 0=no pain and 10=worst pain. Pain was assessed at 5, 10, 15, 20, 25, 30, 35, 40, 45, 60, 120, and 1440 minutes post-op, and the average of all time-points is reported.
Interventions
- DRUG Nicotine (drug)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2003-07 |
| Est. Completion | 2006-03 |
| Phase | Phase 4 |
What the finished NCT00232817 record still lists
NCT00232817 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 23 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Nicotine (drug) is the first listed.
NCT00232817 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00232817 about?
NCT00232817 is a clinical study titled "Anesthesia and Postoperative Pain". The purpose of this study is to compare post-operative pain after anesthesia with either isoflurane or propofol. Each group will be further randomized to receive intranasal nicotine or placebo in order to detect potential pronociceptive action of isoflurane. The study is a randomized, prospective, ...
What is the current status of trial NCT00232817?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 23 participants. The study started on 2003-07. Estimated completion is 2006-03.
What interventions are being tested in trial NCT00232817?
The interventions under investigation include: Nicotine (drug) (DRUG).
Who is sponsoring clinical trial NCT00232817?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00232817's enrollment target sits among peer trials
23 1725th of 2000 higher than 270 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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