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NCT00227448 · ClinicalTrials.gov registry record · Phase 2
Induced Hypertension for Acute Ischemic Stroke
A Phase 2 study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
NCT00227448: Completed Phase 2 study, sponsored by Johns Hopkins University.
NCT00227448 is a Phase 2 study that has completed, run by Johns Hopkins University. The registered enrollment target is 60 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00227448, a Phase 2 study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
Study Summary
The ultimate goal of this multicenter, phase II study is to increase blood pressure until either a neurologic response is seen or a target mean arterial pressure of 30% above baseline is achieved. IV fluids, IV phenylephrine and/or IV norepinephrine are used to rapidly raise mean arterial pressure in a controlled manner as serial assessments of neurologic function are performed.
Interventions
- DRUG intravenous saline
- DRUG intravenous phenylephrine
- DRUG intravenous levophed
- DRUG oral midodrine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2003-06 |
| Est. Completion | 2005-04 |
| Phase | Phase 2 |
What the finished NCT00227448 record still lists
NCT00227448 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower).
The record links to 0 conditions, and to 4 interventions - of which intravenous saline is the first listed.
NCT00227448 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00227448 about?
NCT00227448 is a clinical study titled "Induced Hypertension for Acute Ischemic Stroke". The ultimate goal of this multicenter, phase II study is to increase blood pressure until either a neurologic response is seen or a target mean arterial pressure of 30% above baseline is achieved. IV fluids, IV phenylephrine and/or IV norepinephrine are used to rapidly raise mean arterial pressure i...
What is the current status of trial NCT00227448?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2003-06. Estimated completion is 2005-04.
What interventions are being tested in trial NCT00227448?
The interventions under investigation include: intravenous saline (DRUG), intravenous phenylephrine (DRUG), intravenous levophed (DRUG), oral midodrine (DRUG).
Who is sponsoring clinical trial NCT00227448?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00227448's enrollment target sits among peer trials
60 1027th of 2000 higher than 868 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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