Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT00222235 · ClinicalTrials.gov registry record · Phase 2

Adjunctive Treatment for Decreasing Symptoms of Schizophrenia

A Phase 2 study, sponsored by University of Maryland, Baltimore.

Completed
Registry status
Phase 2
Development phase
240
Enrollment target

NCT00222235: Completed Phase 2 study, sponsored by University of Maryland, Baltimore.

NCT00222235 is a Phase 2 study that has completed, run by University of Maryland, Baltimore. The registered enrollment target is 240 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (80% higher). According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT00222235, a Phase 2 study, has completed, sponsored by University of Maryland, Baltimore.

COMPLETED
Registry status
Phase 2
Development phase
240 participants
Enrollment target

Study Summary

This study will determine the effectiveness of treatment with glycine or d-cycloserine in addition to a normal antipsychotic regimen in improving negative symptoms and cognitive impairments in patients with schizophrenia.

Interventions

  • DRUG placebo
  • DRUG d-cycloserine
  • DRUG glycine

Trial Details

FieldValue
Enrollment Target 240 participants
Start Date 2000-01
Est. Completion 2004-06
Phase Phase 2
University of Maryland, Baltimore

560 total trials

What the finished NCT00222235 record still lists

NCT00222235 is an interventional study that assigns participants to a tested intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (80% higher).

The record links to 0 conditions, and to 3 interventions - of which placebo is the first listed.

NCT00222235 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT00222235 about?

NCT00222235 is a clinical study titled "Adjunctive Treatment for Decreasing Symptoms of Schizophrenia". This study will determine the effectiveness of treatment with glycine or d-cycloserine in addition to a normal antipsychotic regimen in improving negative symptoms and cognitive impairments in patients with schizophrenia.

What is the current status of trial NCT00222235?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 240 participants. The study started on 2000-01. Estimated completion is 2004-06.

What interventions are being tested in trial NCT00222235?

The interventions under investigation include: placebo (DRUG), d-cycloserine (DRUG), glycine (DRUG).

Who is sponsoring clinical trial NCT00222235?

This trial is sponsored by University of Maryland, Baltimore, which has 560 total clinical trials registered on ClinicalTrials.gov.

How this trial's enrollment target compares

Where NCT00222235's enrollment target sits among peer trials

240 239th of 2000 higher than 1,746 of 2,000 other Phase 2 trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT02855554 · 240 participants · NA

    Quantitative Cardiac Parametric Mapping

  • NCT03230565 · 240 participants · Phase 4

    Continuous Infusions vs Scheduled Bolus Infusions

  • NCT03399929 · 240 participants

    Traumatic Brain Injury and Stroke Long Term Outcome

  • NCT03583710 · 240 participants · Phase 3

    Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Patients With Stage I-III Adrenocortical Cancer With High Risk of Recurrence

Similar registry start date

  • NCT05988463 · started 2027-01-01 · Phase 1

    Dose-Escalation Study of Artesunate Patients With IPF

  • NCT07219706 · started 2026-12-10 · NA

    Dietary Fiber and Time Restricted Eating

  • NCT02831335 · started 2026-12-01

    Technical Development of Multi-Parametric Renocerebral MRI

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

Source: ClinicalTrials.gov NCT00222235, the US trial registry maintained by the National Library of Medicine. NCT00222235 (mid enrollment · none site footprint · completed) retrieved and formatted by PlainTrial, see methodology.