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NCT00219492 · ClinicalTrials.gov registry record
Role of Esophageal Mast Cell Activation in Noncardiac Chest Pain (NCCP)
A clinical trial, sponsored by Milton S. Hershey Medical Center.
- Completed
- Registry status
- 86
- Enrollment target
NCT00219492: Completed study, sponsored by Milton S. Hershey Medical Center.
NCT00219492 is a clinical trial that has completed, run by Milton S. Hershey Medical Center. The registered enrollment target is 86 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00219492 has completed, sponsored by Milton S. Hershey Medical Center.
- COMPLETED
- Registry status
- 86 participants
- Enrollment target
Study Summary
Chest pain is a common clinical complaint. About 30% patients with chest pain will have a normal coronary angiogram and are described as having noncardiac chest pain (NCCP). It is estimated that 25% of the population complain of chest pain at some time in their lifetime. The pathogenesis of NCCP is unknown. Esophageal hypersensitivity as a result of inflammation is considered to be an important mechanism in the development of this pain sensation. Little is currently known about the interaction between inflammatory mediators and peripheral afferent nerve terminals in the esophagus. The mast cell is one of the most enriched pro-inflammatory cells in the gastrointestinal tract. Activation of the mucosal mast cell releases a variety of mediators into adjacent tissues. We hypothesize that mediators released by mast cells sensitize esophageal nociceptors and induce pain sensation.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 86 participants |
| Start Date | 2005-09 |
| Est. Completion | 2014-08-21 |
What the finished NCT00219492 record still lists
NCT00219492 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 86 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT00219492 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00219492 about?
NCT00219492 is a clinical study titled "Role of Esophageal Mast Cell Activation in Noncardiac Chest Pain (NCCP)". Chest pain is a common clinical complaint. About 30% patients with chest pain will have a normal coronary angiogram and are described as having noncardiac chest pain (NCCP). It is estimated that 25% of the population complain of chest pain at some time in their lifetime. The pathogenesis of NCCP is ...
What is the current status of trial NCT00219492?
This trial is currently completed. The enrollment target is 86 participants. The study started on 2005-09. Estimated completion is 2014-08-21.
Who is sponsoring clinical trial NCT00219492?
This trial is sponsored by Milton S. Hershey Medical Center, which has 396 total clinical trials registered on ClinicalTrials.gov.
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