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NCT00187681 · ClinicalTrials.gov registry record · Phase 4
Organic Cation Transporter 1 (OCT1), on Response to Metformin in Healthy Subjects
A Phase 4 study, sponsored by University of California, San Francisco.
- Completed
- Registry status
- Phase 4
- Development phase
- 20
- Enrollment target
NCT00187681: Completed Phase 4 study, sponsored by University of California, San Francisco.
NCT00187681 is a Phase 4 study that has completed, run by University of California, San Francisco. The registered enrollment target is 20 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00187681, a Phase 4 study, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 20 participants
- Enrollment target
Study Summary
Specific Objectives: * To determine if individuals who carry a decreased or non-functional variant of OCT1 exhibit differences in the pharmacokinetics of metformin in comparison to individuals who carry the common allele. * To determine if individuals who carry the decreased or non-functional variants exhibit differences in the response to metformin in comparison to individuals who carry the common allele.
Primary Outcome
To test whether individuals with genetic variants of human organic cation transporter, OCT1, exhibit altered pharmacokinetics of metformin, the difference in AUC of blood concentration-time of metformin between reference and variant groups will be measured.
Interventions
- DRUG Metformin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2003-07 |
| Est. Completion | 2008-03 |
| Phase | Phase 4 |
What the finished NCT00187681 record still lists
NCT00187681 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Metformin is the first listed.
NCT00187681 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00187681 about?
NCT00187681 is a clinical study titled "Organic Cation Transporter 1 (OCT1), on Response to Metformin in Healthy Subjects". Specific Objectives: * To determine if individuals who carry a decreased or non-functional variant of OCT1 exhibit differences in the pharmacokinetics of metformin in comparison to individuals who carry the common allele. * To determine if individuals who carry the decreased or non-functional varia...
What is the current status of trial NCT00187681?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 20 participants. The study started on 2003-07. Estimated completion is 2008-03.
What interventions are being tested in trial NCT00187681?
The interventions under investigation include: Metformin (DRUG).
Who is sponsoring clinical trial NCT00187681?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00187681's enrollment target sits among peer trials
20 1753rd of 2000 higher than 167 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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