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NCT00186459 · ClinicalTrials.gov registry record · NA
Obesity, Weight Loss, and Cardiovascular Disease Risk
A NA study, sponsored by Stanford University.
- Completed
- Registry status
- NA
- Development phase
- 58
- Enrollment target
NCT00186459: Completed NA study, sponsored by Stanford University.
NCT00186459 is a NA study that has completed, run by Stanford University. The registered enrollment target is 58 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00186459, a NA study, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- NA
- Development phase
- 58 participants
- Enrollment target
Study Summary
The goal of the study is to define the roles played by resistance to insulin-mediated glucose disposal (insulin resistance) and circulating plasma insulin concentrations in: 1) ability to lose weight; 2) reduction of risk for coronary heart disease as a result of weight loss. We hypothesize that in the setting of caloric restriction, manipulating endogenous insulin concentrations will not alter ability of subjects to lose weight, but will lead to different reduction in CHD risk factors. To test this hypothesis, two parallel studs will be performed. First, obese insulin-resistant individuals will be randomized to one of two equally-hypocaloric diets that vary moderately in proportion of carbohydrate and mono/polyunsaturated fats (lower carbohydrate diet will be associated with greater reduction in endogenous insulin secretion). Second, diabetics treated with insulin secretagogues will be compared to diabetics treated with insulin sensitizers with respect to the same outcomes (secretagogues increase insulin secretion and insulin sensitizers decrease insulin concentrations). Endpoints include weight loss, change in insulin resistance, blood pressure, lipid and lipoproteins, markers of endothelial function, daylong insulin and glucose concentrations: these will be compared, in each of the parallel studies, between the group with insulin-stimulating intervention vs the group with the insulin-sparing intervention.
Interventions
- BEHAVIORAL Hypocaloric diet of varying macronutrient composition
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 58 participants |
| Start Date | 2000-10 |
| Est. Completion | 2017-08-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00186459
The ClinicalTrials.gov registry entry for NCT00186459 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 58 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Stanford University, which has 1,744 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Hypocaloric diet of varying macronutrient composition is the first listed.
NCT00186459 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00186459 about?
NCT00186459 is a clinical study titled "Obesity, Weight Loss, and Cardiovascular Disease Risk". The goal of the study is to define the roles played by resistance to insulin-mediated glucose disposal (insulin resistance) and circulating plasma insulin concentrations in: 1) ability to lose weight; 2) reduction of risk for coronary heart disease as a result of weight loss. We hypothesize that in ...
What is the current status of trial NCT00186459?
This trial is currently completed. It is a NA study. The enrollment target is 58 participants. The study started on 2000-10. Estimated completion is 2017-08-31.
What interventions are being tested in trial NCT00186459?
The interventions under investigation include: Hypocaloric diet of varying macronutrient composition (BEHAVIORAL).
Who is sponsoring clinical trial NCT00186459?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
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