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NCT00186446 · ClinicalTrials.gov registry record · Phase 4
Treatment of Nicotine Dependence and Acute Depression
A Phase 4 study, sponsored by Stanford University.
- Completed
- Registry status
- Phase 4
- Development phase
- 20
- Enrollment target
NCT00186446: Completed Phase 4 study, sponsored by Stanford University.
NCT00186446 is a Phase 4 study that has completed, run by Stanford University. The registered enrollment target is 20 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00186446, a Phase 4 study, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 20 participants
- Enrollment target
Study Summary
The purpose of this study is to assess the safety and feasibility of concurrent treatment of nicotine dependence (cigarette smoking) and acute depression. Participants who meet DSM-IV criteria for both nicotine dependence and acute major depression will be given pharmacological treatment for both disorders at the same time, along with a brief behavioral intervention for smoking cessation.
Primary Outcome
Utilized the Hamilton Depression Rating Scale, 21-item version to assess depressive symptoms, with a range of 0-63. Higher values indicate more depression. % Change in depression score from baseline to week 10. Negative values indicate a reduction in depression.
Interventions
- DRUG bupropion and smoking cessation behavioral intervention
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2004-06 |
| Est. Completion | 2007-09 |
| Phase | Phase 4 |
What the finished NCT00186446 record still lists
NCT00186446 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which bupropion and smoking cessation behavioral intervention is the first listed.
NCT00186446 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00186446 about?
NCT00186446 is a clinical study titled "Treatment of Nicotine Dependence and Acute Depression". The purpose of this study is to assess the safety and feasibility of concurrent treatment of nicotine dependence (cigarette smoking) and acute depression. Participants who meet DSM-IV criteria for both nicotine dependence and acute major depression will be given pharmacological treatment for both di...
What is the current status of trial NCT00186446?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 20 participants. The study started on 2004-06. Estimated completion is 2007-09.
What interventions are being tested in trial NCT00186446?
The interventions under investigation include: bupropion and smoking cessation behavioral intervention (DRUG).
Who is sponsoring clinical trial NCT00186446?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00186446's enrollment target sits among peer trials
20 1753rd of 2000 higher than 167 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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