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NCT00179790 · ClinicalTrials.gov registry record · Phase 1
Reduced Intensity Transplant Using Extracorporeal Photopheresis
A Phase 1 study, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
- Completed
- Registry status
- Phase 1
- Development phase
- 22
- Enrollment target
NCT00179790 is a Phase 1 study that has completed, run by Ann & Robert H Lurie Children's Hospital of Chicago. The registered enrollment target is 22 participants.
The verdict
NCT00179790, a Phase 1 study, has completed, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 22 participants
- Enrollment target
Study Summary
Stem cell transplantation may be used to cure childhood cancers, and other diseases. Traditionally, stem cell transplants use high doses of chemotherapy and radiation. This regimen may cause significant problems after transplant such as infertility, infection, and graft versus host disease (GVHD). Reduced intensity transplant (RIT) uses medications which weaken the immune system, allowing donor cells to take over. The goal of a RIT is to reduce the risk for complications after transplant. Usually medication is used to weaken the immune system, but there are other options such as extracorporeal photopheresis (ECP) that may be less toxic. ECP is currently used for the treatment of GVHD and certain lymphomas. ECP uses a machine that filters white blood cells from the blood, treats them with ultraviolet (UV) light, and then gives all the cells back to the patient. The patient's immune system becomes weaker, allowing the donor cells to replace those of the patient. Studies involving the use of ECP for conditioning have shown fewer side effects than the use of medications. The primary purpose of this clinical research trial is to evaluate the safety and feasibility of ECP as part of a preparative regimen for RIT in children and young adults.
Interventions
- PROCEDURE Extracorporeal Photopheresis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2005-07 |
| Est. Completion | 2015-01 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00179790
The ClinicalTrials.gov registry entry for NCT00179790 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 22 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ann & Robert H Lurie Children's Hospital of Chicago, which has 159 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Extracorporeal Photopheresis is the first listed.
NCT00179790 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00179790 about?
NCT00179790 is a clinical study titled "Reduced Intensity Transplant Using Extracorporeal Photopheresis". Stem cell transplantation may be used to cure childhood cancers, and other diseases. Traditionally, stem cell transplants use high doses of chemotherapy and radiation. This regimen may cause significant problems after transplant such as infertility, infection, and graft versus host disease (GVHD). ...
What is the current status of trial NCT00179790?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 22 participants. The study started on 2005-07. Estimated completion is 2015-01.
What interventions are being tested in trial NCT00179790?
The interventions under investigation include: Extracorporeal Photopheresis (PROCEDURE).
Who is sponsoring clinical trial NCT00179790?
This trial is sponsored by Ann & Robert H Lurie Children's Hospital of Chicago, which has 159 total clinical trials registered on ClinicalTrials.gov.
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