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NCT00144430 · ClinicalTrials.gov registry record · Phase 2
Pentostatin for High Risk and Refractory Chronic Graft Versus Host Disease in Children
A Phase 2 study, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
- Completed
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
NCT00144430: Completed Phase 2 study, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
NCT00144430 is a Phase 2 study that has completed, run by Ann & Robert H Lurie Children's Hospital of Chicago. The registered enrollment target is 60 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00144430, a Phase 2 study, has completed, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
Study Summary
This is a multicenter trial through the Pediatric Blood and Marrow Transplant Consortium. The Primary hypothesis of this study is that because of its effect as a potent immunosuppressive agent targeting lymphocytes, pentostatin will show a sustained response in pediatric subjects with severe chronic GVHD. Secondary hypotheses include that the infection and toxicity rate of pentostatin in this setting will be acceptable given its lack of severe myelosuppression, and subjects with refractory chronic GVHD will have significant QOL impairment and symptomatology. These may change as subjects are being treated for their chronic GVHD with pentostatin.
Interventions
- DRUG Pentostatin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2004-01 |
| Est. Completion | 2008-08 |
| Phase | Phase 2 |
What the finished NCT00144430 record still lists
NCT00144430 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower).
The record links to 0 conditions, and to 1 intervention - of which Pentostatin is the first listed.
NCT00144430 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00144430 about?
NCT00144430 is a clinical study titled "Pentostatin for High Risk and Refractory Chronic Graft Versus Host Disease in Children". This is a multicenter trial through the Pediatric Blood and Marrow Transplant Consortium. The Primary hypothesis of this study is that because of its effect as a potent immunosuppressive agent targeting lymphocytes, pentostatin will show a sustained response in pediatric subjects with severe chroni...
What is the current status of trial NCT00144430?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2004-01. Estimated completion is 2008-08.
What interventions are being tested in trial NCT00144430?
The interventions under investigation include: Pentostatin (DRUG).
Who is sponsoring clinical trial NCT00144430?
This trial is sponsored by Ann & Robert H Lurie Children's Hospital of Chicago, which has 159 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00144430's enrollment target sits among peer trials
60 1027th of 2000 higher than 868 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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