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NCT00067106 · ClinicalTrials.gov registry record
Antiviral Therapy and HIV in the Female Genital Tract
A clinical trial of HIV Infections, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- Completed
- Registry status
- 130
- Enrollment target
- 1
- Study location
NCT00067106: Completed study of HIV Infections, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
NCT00067106 is a study of HIV Infections that has completed, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 130 participants, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00067106, a study of HIV Infections, has completed, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- COMPLETED
- Registry status
- 130 participants
- Enrollment target
- 1
- Study location
Study Summary
HIV is found in both the blood and the genital tract. This study will compare the levels and types of HIV found in the blood with the levels and types of HIV found in the female genital tract. Study hypotheses: 1) In the presence of antiretroviral therapy, viral replication within the female genital tract may lead to the development of drug resistance that is different from that of virus in the blood plasma. 2) Antiretroviral drug levels in the female genital tract may often be lower than in the blood plasma and differences in drug exposure may be associated with differences in virus replication and selection of resistant HIV variants during drug failure. 3) HIV can be recovered in vitro from cells in the female genital tract during successful therapy, and it may be genetically different from the HIV variants recovered from the blood cell latent reservoir on the same visit.
Primary Outcome
The primary analysis will be to compare resistance mutation patterns in blood plasma versus CVL population sequences.
Conditions Studied
Study Locations (1)
Rhode Island
- The Miriam Hospital - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 130 participants |
| Start Date | 2003-07 |
| Est. Completion | 2009-03 |
What the finished NCT00067106 record still lists
NCT00067106 is an observational study that tracks outcomes without assigning an intervention. The registered 130 participants enrollment target is mid-sized for trials with a published cap, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (71% lower).
The record links to 1 condition, with HIV Infections appearing as the primary indexed condition, and to 0 interventions.
NCT00067106 reports a single indexed study location in Rhode Island.
Frequently Asked Questions
What is clinical trial NCT00067106 about?
NCT00067106 is a clinical study titled "Antiviral Therapy and HIV in the Female Genital Tract". HIV is found in both the blood and the genital tract. This study will compare the levels and types of HIV found in the blood with the levels and types of HIV found in the female genital tract. Study hypotheses: 1) In the presence of antiretroviral therapy, viral replication within the female genita...
What is the current status of trial NCT00067106?
This trial is currently completed. The enrollment target is 130 participants. The study started on 2003-07. Estimated completion is 2009-03.
What conditions does trial NCT00067106 study?
This clinical trial studies the following conditions: HIV Infections.
Who is sponsoring clinical trial NCT00067106?
This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00067106 being conducted?
This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00067106's enrollment target sits among peer trials
130 227th of 542 higher than 313 of 542 other HIV Infections trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other HIV Infections trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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