Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 3

Doxorubicin Hydrochloride, Cisplatin, and Paclitaxel or Carboplatin and Paclitaxel in Treating Patients With Stage III-IV or Recurrent Endometrial Cancer

NCT00063999 · View on ClinicalTrials.gov ↗

Study Summary

This randomized phase III trial compares how well two different combination chemotherapy regimens (doxorubicin hydrochloride, cisplatin, and paclitaxel versus carboplatin and paclitaxel) work in treating patients with endometrial cancer that is stage III-IV or has come back (recurrent). Drugs used in chemotherapy such as doxorubicin hydrochloride, cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known which combination chemotherapy regimen is more effective in treating endometrial cancer.

Interventions

  • DRUG Carboplatin
  • DRUG Cisplatin
  • OTHER Laboratory Biomarker Analysis
  • DRUG Doxorubicin Hydrochloride
  • BIOLOGICAL Filgrastim

Study Locations (20)

California

  • Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank
  • John Muir Medical Center-Concord Campus — Concord
  • City of Hope Comprehensive Cancer Center — Duarte
  • Kaiser Permanente-Fremont — Fremont
  • Saint Jude Medical Center — Fullerton
  • Marin Cancer Care Inc — Greenbrae
  • Long Beach Memorial Medical Center-Todd Cancer Institute — Long Beach
  • Kaiser Permanente Los Angeles Medical Center — Los Angeles
  • USC / Norris Comprehensive Cancer Center — Los Angeles
  • Cedars Sinai Medical Center — Los Angeles
  • UCLA / Jonsson Comprehensive Cancer Center — Los Angeles

Alabama

  • University of Alabama at Birmingham Cancer Center — Birmingham
  • Clearview Cancer Institute — Huntsville
  • Mobile Infirmary Medical Center — Mobile
  • Providence Hospital — Mobile

Arkansas

  • Highlands Oncology Group PA - Fayetteville — Fayetteville
  • Washington Regional Medical Center - Fayetteville — Fayetteville
  • University of Arkansas for Medical Sciences — Little Rock

Alaska

  • Providence Alaska Medical Center — Anchorage

Arizona

  • Mayo Clinic in Arizona — Scottsdale

Trial Details

FieldValue
Enrollment Target 1,381 participants
Start Date 2003-08-25
Est. Completion 2021-01-05
Phase Phase 3

Sponsor

GOG Foundation

37 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00063999

The ClinicalTrials.gov registry entry for NCT00063999 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,381 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GOG Foundation, which has 37 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 6 conditions, with Recurrent Uterine Corpus Carcinoma appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00063999 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Alabama, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00063999 about?

NCT00063999 is a clinical study titled "Doxorubicin Hydrochloride, Cisplatin, and Paclitaxel or Carboplatin and Paclitaxel in Treating Patients With Stage III-IV or Recurrent Endometrial Cancer". This randomized phase III trial compares how well two different combination chemotherapy regimens (doxorubicin hydrochloride, cisplatin, and paclitaxel versus carboplatin and paclitaxel) work in treating patients with endometrial cancer that is stage III-IV or has come back (recurrent). Drugs used i...

What is the current status of trial NCT00063999?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 1,381 participants. The study started on 2003-08-25. Estimated completion is 2021-01-05.

What conditions does trial NCT00063999 study?

This clinical trial studies the following conditions: Recurrent Uterine Corpus Carcinoma, Stage IIIA Uterine Corpus Cancer AJCC v7, Stage IIIB Uterine Corpus Cancer AJCC v7, Stage IIIC Uterine Corpus Cancer AJCC v7, Stage IVA Uterine Corpus Cancer AJCC v7. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00063999?

The interventions under investigation include: Carboplatin (DRUG), Cisplatin (DRUG), Laboratory Biomarker Analysis (OTHER), Doxorubicin Hydrochloride (DRUG), Filgrastim (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00063999?

This trial is sponsored by GOG Foundation, which has 37 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00063999 being conducted?

This trial has 20 study locations across Alabama, Alaska, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial