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NCT00052780 · ClinicalTrials.gov registry record · Phase 1
Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors
A Phase 1 study of Childhood Central Nervous System Germ Cell Tumor and Childhood High-grade Cerebral Astrocytoma, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- Phase 1
- Development phase
- 72
- Enrollment target
- 1
- Study location
NCT00052780: Completed Phase 1 study of Childhood Central Nervous System Germ Cell Tumor and Childhood High-grade Cerebral Astrocytoma, sponsored by National Cancer Institute (NCI).
NCT00052780 is a Phase 1 study of Childhood Central Nervous System Germ Cell Tumor and Childhood High-grade Cerebral Astrocytoma that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 72 participants, below the 83-participant average among 3 other Childhood Central Nervous System Germ Cell Tumor trials with a reported enrollment target (13% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00052780, a Phase 1 study of Childhood Central Nervous System Germ Cell Tumor and Childhood High-grade Cerebral Astrocytoma, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 72 participants
- Enrollment target
- 1
- Study location
Study Summary
Phase I trial to study the safety of combining O6-benzylguanine with temozolomide in treating children who have recurrent or refractory brain tumors. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. O6-benzylguanine may increase the effectiveness of temozolomide by making tumor cells more sensitive to the drug.
Conditions Studied
Interventions
- OTHER laboratory biomarker analysis
- DRUG O6-benzylguanine
- DRUG temozolomide
- OTHER pharmacological study
- BIOLOGICAL filgrastim
Study Locations (1)
Tennessee
- Pediatric Brain Tumor Consortium - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 72 participants |
| Start Date | 2002-10 |
| Phase | Phase 1 |
What the finished NCT00052780 record still lists
NCT00052780 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 72 participants, a relatively small participant target, below the 83-participant average among 3 other Childhood Central Nervous System Germ Cell Tumor trials with a reported enrollment target (13% lower).
The record links to 10 conditions, with Childhood Central Nervous System Germ Cell Tumor appearing as the primary indexed condition, and to 5 interventions - of which laboratory biomarker analysis is the first listed.
NCT00052780 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT00052780 about?
NCT00052780 is a clinical study titled "Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors". Phase I trial to study the safety of combining O6-benzylguanine with temozolomide in treating children who have recurrent or refractory brain tumors. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. O6-benzylguanine may increase the effecti...
What is the current status of trial NCT00052780?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 72 participants. The study started on 2002-10.
What conditions does trial NCT00052780 study?
This clinical trial studies the following conditions: Childhood Central Nervous System Germ Cell Tumor, Childhood High-grade Cerebral Astrocytoma, Childhood Infratentorial Ependymoma, Childhood Choroid Plexus Tumor, Childhood Craniopharyngioma.
What interventions are being tested in trial NCT00052780?
The interventions under investigation include: laboratory biomarker analysis (OTHER), O6-benzylguanine (DRUG), temozolomide (DRUG), pharmacological study (OTHER), filgrastim (BIOLOGICAL).
Who is sponsoring clinical trial NCT00052780?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00052780 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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