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NCT00026910 · ClinicalTrials.gov registry record
Analysis of Molecular Markers of Drug Resistance in Tumor Biopsies From Previously Untreated Aggressive Non-Hodgkin's Lymphoma
A clinical trial, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- 200
- Enrollment target
NCT00026910: Completed study, sponsored by National Cancer Institute (NCI).
NCT00026910 is a clinical trial that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 200 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00026910 has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- 200 participants
- Enrollment target
Study Summary
Although the cause(s) of clinical drug resistance in non-Hodgkin's lymphomas (NHL) are unknown, in vitro studies suggest that abnormalities of the cell cycle and mechanisms of apoptosis may play an important role. Clinical studies have now shown that p53, bcl-2 and tumor proliferation all have significant effects on clinical drug resistance. To further investigate the role of genes that control the cell cycle and apoptosis, we wish to correlate the expression of multiple molecular targets \[including but not restricted to bcl-2, BAX, bcl-6, MIB-1, p53, p21, p27, p16, cyclin D(1), cyclin A, cyclin E, mdm-2, cpp 32, mcl-1, EBER-1, ALK, and a panel of B, T and other cell lineage markers\], involving these pathways, with clinical outcome following treatment with combination chemotherapy. All clinical data and tissue samples for this study will come from patients who have been previously enrolled on two protocols for the initial treatment of aggressive lymphomas. No new patients will be enrolled for this study.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 1998-07 |
| Est. Completion | 2002-05 |
What the finished NCT00026910 record still lists
NCT00026910 is an observational study that tracks outcomes without assigning an intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT00026910 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00026910 about?
NCT00026910 is a clinical study titled "Analysis of Molecular Markers of Drug Resistance in Tumor Biopsies From Previously Untreated Aggressive Non-Hodgkin's Lymphoma". Although the cause(s) of clinical drug resistance in non-Hodgkin's lymphomas (NHL) are unknown, in vitro studies suggest that abnormalities of the cell cycle and mechanisms of apoptosis may play an important role. Clinical studies have now shown that p53, bcl-2 and tumor proliferation all have signi...
What is the current status of trial NCT00026910?
This trial is currently completed. The enrollment target is 200 participants. The study started on 1998-07. Estimated completion is 2002-05.
Who is sponsoring clinical trial NCT00026910?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
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