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NCT00026221 · ClinicalTrials.gov registry record · Phase 2
Bevacizumab With or Without Interferon Alfa in Treating Patients With Metastatic Malignant Melanoma
A Phase 2 study, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- Phase 2
- Development phase
- 57
- Enrollment target
NCT00026221: Completed Phase 2 study, sponsored by National Cancer Institute (NCI).
NCT00026221 is a Phase 2 study that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 57 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (57% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00026221, a Phase 2 study, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 57 participants
- Enrollment target
Study Summary
This randomized phase II trial is studying giving bevacizumab together with interferon alpha to see how well it works compared to giving bevacizumab alone in treating patients with metastatic malignant melanoma. Monoclonal antibodies, such as bevacizumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or deliver cancer-killing substances to them. Interferon alpha may interfere with the growth of the cancer cells and slow the growth of the tumor. Combining bevacizumab with interferon alpha may kill more tumor cells.
Primary Outcome
Measured from the time measurement criteria are met for complete response (CR) or partial response (PR) (whichever is first recorded) until the first date that recurrent or progressive disease is objectively documented. Evaluated using the new international criteria proposed by the Response Evaluation Criteria in Solid Tumors (RECIST) Committee. Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0) for target lesions and assessed by MRI: Complete Response (CR), Disappearance of
Interventions
- BIOLOGICAL Bevacizumab
- BIOLOGICAL Recombinant Interferon Alfa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 57 participants |
| Start Date | 2001-11 |
| Est. Completion | 2013-11 |
| Phase | Phase 2 |
What the finished NCT00026221 record still lists
NCT00026221 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 57 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (57% lower).
The record links to 0 conditions, and to 2 interventions - of which Bevacizumab is the first listed.
NCT00026221 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00026221 about?
NCT00026221 is a clinical study titled "Bevacizumab With or Without Interferon Alfa in Treating Patients With Metastatic Malignant Melanoma". This randomized phase II trial is studying giving bevacizumab together with interferon alpha to see how well it works compared to giving bevacizumab alone in treating patients with metastatic malignant melanoma. Monoclonal antibodies, such as bevacizumab, can block cancer growth in different ways. S...
What is the current status of trial NCT00026221?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 57 participants. The study started on 2001-11. Estimated completion is 2013-11.
What interventions are being tested in trial NCT00026221?
The interventions under investigation include: Bevacizumab (BIOLOGICAL), Recombinant Interferon Alfa (BIOLOGICAL).
Who is sponsoring clinical trial NCT00026221?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00026221's enrollment target sits among peer trials
57 1141st of 2000 higher than 855 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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