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NCT00018148 · ClinicalTrials.gov registry record · Phase 2
Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation
A Phase 2 study, sponsored by US Department of Veterans Affairs.
- Completed
- Registry status
- Phase 2
- Development phase
- 158
- Enrollment target
NCT00018148: Completed Phase 2 study, sponsored by US Department of Veterans Affairs.
NCT00018148 is a Phase 2 study that has completed, run by US Department of Veterans Affairs. The registered enrollment target is 158 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (19% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00018148, a Phase 2 study, has completed, sponsored by US Department of Veterans Affairs.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 158 participants
- Enrollment target
Study Summary
Treatment of smokers with a tricyclic antidepressant, nortriptyline, can reduce tobacco withdrawal symptoms and increases long term cessation rates when combined with transdermal nicotine and a behavioral cessation programs. The study is a placebo-controlled, randomized, parallel group trial in which smokers aged 18-70 will be subject to the combination of oral and patch treatments.
Interventions
- DRUG transdermal nicotine
- DRUG nortriptyline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 158 participants |
| Start Date | 1998-04 |
| Est. Completion | 2003-01 |
| Phase | Phase 2 |
What the finished NCT00018148 record still lists
NCT00018148 is an interventional study that assigns participants to a tested intervention. The registered 158 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (19% higher).
The record links to 0 conditions, and to 2 interventions - of which transdermal nicotine is the first listed.
NCT00018148 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00018148 about?
NCT00018148 is a clinical study titled "Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation". Treatment of smokers with a tricyclic antidepressant, nortriptyline, can reduce tobacco withdrawal symptoms and increases long term cessation rates when combined with transdermal nicotine and a behavioral cessation programs. The study is a placebo-controlled, randomized, parallel group trial in whic...
What is the current status of trial NCT00018148?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 158 participants. The study started on 1998-04. Estimated completion is 2003-01.
What interventions are being tested in trial NCT00018148?
The interventions under investigation include: transdermal nicotine (DRUG), nortriptyline (DRUG).
Who is sponsoring clinical trial NCT00018148?
This trial is sponsored by US Department of Veterans Affairs, which has 632 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00018148's enrollment target sits among peer trials
158 443rd of 2000 higher than 1,558 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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