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NCT00006434 · ClinicalTrials.gov registry record · Phase 3
Tumor Lysate Pulsed-Dendritic Cell Vaccines After High-Dose Chemotherapy for Non-Hodgkin's Lymphoma
A Phase 3 study, sponsored by National Center for Research Resources (NCRR).
- Completed
- Registry status
- Phase 3
- Development phase
NCT00006434: Completed Phase 3 study, sponsored by National Center for Research Resources (NCRR).
NCT00006434 is a Phase 3 study that has completed, run by National Center for Research Resources (NCRR). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00006434, a Phase 3 study, has completed, sponsored by National Center for Research Resources (NCRR).
- COMPLETED
- Registry status
- Phase 3
- Development phase
Study Summary
When patients relapse after primary chemotherapy for Non-Hodgkin's lymphoma, they may be eligible to receive high-dose chemotherapy with autologous stem cell support. Unfortunately high-dose chemotherapy is curative in less than half the patients who receive it. This study is being conducted to determine the safety, side effects, and the ability to respond to an investigational vaccine that consists of tumor-pulsed dendritic cells given with an immune stimulating drug called interleukin-2. The patient must have a lymphomatous node accessible for excision to prepare the vaccine. Dendritic cells are immune cells that are obtained from the blood, and are important in the body's immune response to foreign substances. This study will examine the response of the immune system after three vaccinations (composed of dendritic cells, which have been exposed to dead fragments of lymphoma cells) given beginning three months after transplant. Vaccination may result in sensitizing the patient's dendritic cells to his lymphoma cells, potentially resulting in an immune response against the lymphoma. Twelve patients will be treated on study.
Interventions
- BIOLOGICAL tumor-pulsed dendritic cells
Trial Details
| Field | Value |
|---|---|
| Phase | Phase 3 |
What the finished NCT00006434 record still lists
NCT00006434 is an interventional study that assigns participants to a tested intervention. An enrollment target was not published in the registry record, which is common for early-stage or observational entries.
The record links to 0 conditions, and to 1 intervention - of which tumor-pulsed dendritic cells is the first listed.
NCT00006434 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00006434 about?
NCT00006434 is a clinical study titled "Tumor Lysate Pulsed-Dendritic Cell Vaccines After High-Dose Chemotherapy for Non-Hodgkin's Lymphoma". When patients relapse after primary chemotherapy for Non-Hodgkin's lymphoma, they may be eligible to receive high-dose chemotherapy with autologous stem cell support. Unfortunately high-dose chemotherapy is curative in less than half the patients who receive it. This study is being conducted to dete...
What is the current status of trial NCT00006434?
This trial is currently completed. It is a Phase 3 study.
What interventions are being tested in trial NCT00006434?
The interventions under investigation include: tumor-pulsed dendritic cells (BIOLOGICAL).
Who is sponsoring clinical trial NCT00006434?
This trial is sponsored by National Center for Research Resources (NCRR), which has 94 total clinical trials registered on ClinicalTrials.gov.