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COMPLETED NA

Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization

NCT00004430 · View on ClinicalTrials.gov ↗

Study Summary

OBJECTIVES: I. Demonstrate the safety and efficacy of dihematoporphyrin derivative (DHP) in laser photodynamic therapy (PDT) in patients with corneal neovascularization. II. Document the histopathologic mechanism of action in selected patients undergoing penetrating keratoplasty following PDT therapy for corneal neovascularization. III. Facilitate FDA product approval of DHP as a photosensitizing agent for laser treatment in these patients. IV. Explore the use of this photosensitizer for ocular and cutaneous basal cell and squamous cell carcinoma.

Conditions Studied

Interventions

  • DRUG prednisolone
  • DRUG Dihematoporphyrin derivative
  • PROCEDURE Laser surgery

Study Locations (1)

Virginia

  • Eastern Virginia Medical School — Norfolk

Trial Details

FieldValue
Enrollment Target 150 participants
Start Date 1994-09
Est. Completion 1998-09
Phase NA

Sponsor

Medical College of Hampton Roads

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00004430

The ClinicalTrials.gov registry entry for NCT00004430 describes a study currently listed as completed. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 150 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Medical College of Hampton Roads, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Corneal Neovascularization appearing as the primary indexed condition, and to 3 interventions — of which prednisolone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00004430 reports 1 study location spanning 1 distinct geographic area — top geographies include Virginia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00004430 about?

NCT00004430 is a clinical study titled "Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization". OBJECTIVES: I. Demonstrate the safety and efficacy of dihematoporphyrin derivative (DHP) in laser photodynamic therapy (PDT) in patients with corneal neovascularization. II. Document the histopathologic mechanism of action in selected patients undergoing penetrating keratoplasty following PDT ther...

What is the current status of trial NCT00004430?

This trial is currently completed. It is a NA study. The enrollment target is 150 participants. The study started on 1994-09. Estimated completion is 1998-09.

What conditions does trial NCT00004430 study?

This clinical trial studies the following conditions: Corneal Neovascularization. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00004430?

The interventions under investigation include: prednisolone (DRUG), Dihematoporphyrin derivative (DRUG), Laser surgery (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00004430?

This trial is sponsored by Medical College of Hampton Roads, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00004430 being conducted?

This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial