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NCT00003954 · ClinicalTrials.gov registry record · Phase 1
Melphalan and Stem Cell Transplant Before Total-Body Irradiation and Donor Stem Cell Transplant in Treating Patients With Stage I-III Multiple Myeloma
A Phase 1 study, sponsored by Fred Hutchinson Cancer Center.
- Completed
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
NCT00003954: Completed Phase 1 study, sponsored by Fred Hutchinson Cancer Center.
NCT00003954 is a Phase 1 study that has completed, run by Fred Hutchinson Cancer Center. The registered enrollment target is 40 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00003954, a Phase 1 study, has completed, sponsored by Fred Hutchinson Cancer Center.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
Study Summary
In this study donor bone marrow transplantation is divided into a two step process to try to significantly reduce the side effects of the procedure yet still provide patients with multiple myeloma the benefits of this procedure
Primary Outcome
The current study will be regarded as potentially efficacious if the observed 3-year PFS rate among all patients treated exceeds 30%. The Kaplan-Meier (KM) estimate of PFS will be used.
Interventions
- PROCEDURE autologous hematopoietic stem cell transplantation
- DRUG melphalan
- PROCEDURE peripheral blood stem cell transplantation
- RADIATION total-body irradiation
- PROCEDURE autologous bone marrow transplantation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 1999-03 |
| Phase | Phase 1 |
What the finished NCT00003954 record still lists
NCT00003954 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower).
The record links to 0 conditions, and to 5 interventions - of which autologous hematopoietic stem cell transplantation is the first listed.
NCT00003954 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00003954 about?
NCT00003954 is a clinical study titled "Melphalan and Stem Cell Transplant Before Total-Body Irradiation and Donor Stem Cell Transplant in Treating Patients With Stage I-III Multiple Myeloma". In this study donor bone marrow transplantation is divided into a two step process to try to significantly reduce the side effects of the procedure yet still provide patients with multiple myeloma the benefits of this procedure
What is the current status of trial NCT00003954?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 1999-03.
What interventions are being tested in trial NCT00003954?
The interventions under investigation include: autologous hematopoietic stem cell transplantation (PROCEDURE), melphalan (DRUG), peripheral blood stem cell transplantation (PROCEDURE), total-body irradiation (RADIATION), autologous bone marrow transplantation (PROCEDURE).
Who is sponsoring clinical trial NCT00003954?
This trial is sponsored by Fred Hutchinson Cancer Center, which has 483 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00003954's enrollment target sits among peer trials
40 1130th of 2000 higher than 810 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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