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NCT00000431 · ClinicalTrials.gov registry record · Phase 1
Preliminary Testing of New Treatment for Chronic Leg Wounds
A Phase 1 study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
NCT00000431: Completed Phase 1 study, sponsored by University of Pennsylvania.
NCT00000431 is a Phase 1 study that has completed, run by University of Pennsylvania. The registered enrollment target is 24 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (60% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00000431, a Phase 1 study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
Study Summary
Most chronic (long-lasting) wounds of the leg (also known as venous ulcers) fail to heal in a reasonable period of time. Although researchers have made great progress in understanding how the body repairs wounds, attempts to develop new treatments have been disappointing. In general, treatments based on recent findings about the details of wound repair have not greatly reduced the number of people who have chronic wounds. The long-term goal of this study is to evaluate a new approach for healing a chronic wound. Current methods of directly applying substances that are involved in wound healing to a chronic wound do not cause enough healing. PDGF-B (platelet-derived growth factor B), a factor associated with wound healing, might dramatically enhance healing if a genetically engineered virus is injected into the wound that causes cells in the wound to produce PDGF-B in large quantities.
Interventions
- DRUG PDGF-B/Ad5
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2005-01 |
| Est. Completion | 2011-03 |
| Phase | Phase 1 |
What the finished NCT00000431 record still lists
NCT00000431 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (60% lower).
The record links to 0 conditions, and to 1 intervention - of which PDGF-B/Ad5 is the first listed.
NCT00000431 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00000431 about?
NCT00000431 is a clinical study titled "Preliminary Testing of New Treatment for Chronic Leg Wounds". Most chronic (long-lasting) wounds of the leg (also known as venous ulcers) fail to heal in a reasonable period of time. Although researchers have made great progress in understanding how the body repairs wounds, attempts to develop new treatments have been disappointing. In general, treatments base...
What is the current status of trial NCT00000431?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2005-01. Estimated completion is 2011-03.
What interventions are being tested in trial NCT00000431?
The interventions under investigation include: PDGF-B/Ad5 (DRUG).
Who is sponsoring clinical trial NCT00000431?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00000431's enrollment target sits among peer trials
24 1520th of 2000 higher than 405 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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