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NCT00000425 · ClinicalTrials.gov registry record · Phase 3
Toward Better Outcomes in Osteoarthritis
A Phase 3 study, sponsored by Stanford University.
- Completed
- Registry status
- Phase 3
- Development phase
- 900
- Enrollment target
NCT00000425: Completed Phase 3 study, sponsored by Stanford University.
NCT00000425 is a Phase 3 study that has completed, run by Stanford University. The registered enrollment target is 900 participants, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (17% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00000425, a Phase 3 study, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 900 participants
- Enrollment target
Study Summary
This study will determine if there is a difference between commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (a pain-reliever that does not prevent inflammation) for treating knee pain in osteoarthritis (OA). The two main results we will look at are disease progression according to x-rays and disability over 3.5 years. Study participants with moderate knee OA and knee pain will continue taking their NSAID or stop taking their NSAID and start taking acetaminophen. Every 6 months we will send the participants questionnaires that ask about pain, medication use, and disability. We will take x-rays of the knees at the start of the study and again at the end of the study.
Interventions
- DRUG Acetaminophen
- DRUG Nonsteroidal anti-inflammatory drugs (NSAIDs)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 900 participants |
| Start Date | 1996-07 |
| Est. Completion | 2001-04 |
| Phase | Phase 3 |
What the finished NCT00000425 record still lists
NCT00000425 is an interventional study that assigns participants to a tested intervention. The registered 900 participants enrollment target is mid-sized for trials with a published cap, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (17% higher).
The record links to 0 conditions, and to 2 interventions - of which Acetaminophen is the first listed.
NCT00000425 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00000425 about?
NCT00000425 is a clinical study titled "Toward Better Outcomes in Osteoarthritis". This study will determine if there is a difference between commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (a pain-reliever that does not prevent inflammation) for treating knee pain in osteoarthritis (OA). The two main results we will look at are disease progression ac...
What is the current status of trial NCT00000425?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 900 participants. The study started on 1996-07. Estimated completion is 2001-04.
What interventions are being tested in trial NCT00000425?
The interventions under investigation include: Acetaminophen (DRUG), Nonsteroidal anti-inflammatory drugs (NSAIDs) (DRUG).
Who is sponsoring clinical trial NCT00000425?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00000425's enrollment target sits among peer trials
900 350th of 2000 higher than 1,641 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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