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NCT00000403 · ClinicalTrials.gov registry record · Phase 3
Doxycycline and OA Progression
A Phase 3 study, sponsored by Indiana University.
- Completed
- Registry status
- Phase 3
- Development phase
- 432
- Enrollment target
NCT00000403 is a Phase 3 study that has completed, run by Indiana University. The registered enrollment target is 432 participants.
The verdict
NCT00000403, a Phase 3 study, has completed, sponsored by Indiana University.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 432 participants
- Enrollment target
Study Summary
This study will determine whether doxycycline decreases the severity or rate of progression of osteoarthritis (OA) in the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most popular agents used to treat OA, but elderly women, in whom OA is especially common, are at greatest risk of developing serious side effects from NSAIDs. Our study targets overweight middle-aged women who have OA in one knee. Half of the 432 study participants will receive the treatment (doxycycline) and half will receive a placebo (inactive pill). Treatment with doxycycline (or placebo) will last 30 months, and participants and researchers will not know who is receiving doxycycline and who is receiving placebo until the end of the study. We will look for narrowing of the joint space in the knee that was not affected by OA at the start of the study. Joint space narrowing is a sign of OA. We will also use questionnaires to evaluate participants' symptoms and functioning.
Interventions
- DRUG Doxycycline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 432 participants |
| Start Date | 1996-09 |
| Est. Completion | 2001-07 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00000403
The ClinicalTrials.gov registry entry for NCT00000403 describes a study currently listed as completed, categorized as Phase 3. The registered enrollment target is 432 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Indiana University, which has 890 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Doxycycline is the first listed.
NCT00000403 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00000403 about?
NCT00000403 is a clinical study titled "Doxycycline and OA Progression". This study will determine whether doxycycline decreases the severity or rate of progression of osteoarthritis (OA) in the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most popular agents used to treat OA, but elderly women, in whom OA is especially common, are at greatest risk of deve...
What is the current status of trial NCT00000403?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 432 participants. The study started on 1996-09. Estimated completion is 2001-07.
What interventions are being tested in trial NCT00000403?
The interventions under investigation include: Doxycycline (DRUG).
Who is sponsoring clinical trial NCT00000403?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
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