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NCT00000395 · ClinicalTrials.gov registry record · Phase 2
Antifolate Effectiveness in Arthritis
A Phase 2 study, sponsored by University of Alabama at Birmingham.
- Completed
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
NCT00000395: Completed Phase 2 study, sponsored by University of Alabama at Birmingham.
NCT00000395 is a Phase 2 study that has completed, run by University of Alabama at Birmingham. The registered enrollment target is 40 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (70% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00000395, a Phase 2 study, has completed, sponsored by University of Alabama at Birmingham.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
Study Summary
This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the action of the B-vitamin known as folic acid. We are studying the biochemical reactions affected by this vitamin because we think that blocking many of these reactions may be necessary for methotrexate to work in treating rheumatoid arthritis. Through these studies, we hope to gain a better understanding of how this drug and related drugs work as treatments for arthritis.
Interventions
- DRUG Methotrexate
- DIETARY_SUPPLEMENT Folic acid
- DIETARY_SUPPLEMENT Folinic acid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 1996-09 |
| Est. Completion | 2002-08 |
| Phase | Phase 2 |
What the finished NCT00000395 record still lists
NCT00000395 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (70% lower).
The record links to 0 conditions, and to 3 interventions - of which Methotrexate is the first listed.
NCT00000395 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00000395 about?
NCT00000395 is a clinical study titled "Antifolate Effectiveness in Arthritis". This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the action of the B-vitamin known as folic acid. We are studying the biochemical reactions affected by th...
What is the current status of trial NCT00000395?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 1996-09. Estimated completion is 2002-08.
What interventions are being tested in trial NCT00000395?
The interventions under investigation include: Methotrexate (DRUG), Folic acid (DIETARY_SUPPLEMENT), Folinic acid (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT00000395?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00000395's enrollment target sits among peer trials
40 1362nd of 2000 higher than 542 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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