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Critical Limb Ischemia: early-phase trial registry
8 of 19 indexed Critical Limb Ischemia trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #903 of 28,963 conditions by registered trial count.
19 US clinical trials · 8 currently recruiting · #903 of 28,963 conditions by registered trial count
Critical Limb Ischemia: 19 US clinical trials tracked, 8 recruiting.
Critical Limb Ischemia is the subject of 19 registered US clinical trials on ClinicalTrials.gov, 8 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is LimFlow, running 2 of these trials.
Open enrollment, early-phase tilt
Critical Limb Ischemia has 19 registered US clinical trials, 8 of them open to new participants right now, about 42% of the total.
- 8
- recruiting participants now
- 42%
- of trials open to enrollment
- 3
- in Phase 3-4 (later-stage)
- 2
- top sponsor: LimFlow
Corpus placement: #903 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Critical Limb Ischemia on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Critical Limb Ischemia is recruiting below its size-band peers.
8 of 19 indexed trials (42.1%) are open to enrollment, against a 46.5% average across 28,061 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Critical Limb Ischemia trials is spread across many organizations.
LimFlow accounts for 2 of 19 trials (10.5%). 17 distinct sponsors appear on at least one study for this condition label.
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Most Critical Limb Ischemia trials plan to enrol fewer than 100 people.
Median target enrolment is 41 among the 19 trials that report a genuine target (sentinel values excluded). 14 of those (73.7%) plan for fewer than 100 participants.
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Critical Limb Ischemia research is mostly interventional.
16 interventional and 3 observational studies make up this index (84.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
19 total, page 1 of 1
MOTIV BTK Randomized Controlled Trial
REVA Medical
NCT05406622
Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee
Mercator MedSystems
NCT04433572
PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
LimFlow
NCT05313165
Serrantor OCT Study
Cagent Vascular
NCT06434194
Trial to Assess Chelation Therapy in Critical Limb Ischemia
Mt. Sinai Medical Center, Miami
NCT03982693
CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions
Yale University
NCT05145478
Nutrition in Patient With Critical Limb Ischemia
Boston Medical Center
NCT03529019
Use of Thermal Imaging Camera to Assess Perfusion Before and After Vascular Intervention
University Hospitals Cleveland Medical Center
NCT06544135
Lutonix DCB Versus Standard Balloon Angioplasty for Treatment of Below-The-Knee (BTK) Arteries
C. R. Bard
NCT01870401
A Prospective Single-Arm Multicenter StuDy of the BarE TEmporary SPur StEnt System foR the tREatment of Vascular Lesions Located in the infrapoplitEal Arteries beLow the Knee (DEEPER REVEAL)
ReFlow Medical
NCT05358353
Switch to Ticagrelor in Critical Limb Ischemia Anti-platelet Study
University of Southern California
NCT02091921
An Efficacy and Safety Study of Ixmyelocel-T in Patients With Critical Limb Ischemia (CLI)
Vericel Corporation
NCT01483898
Imaging-Guided Vessel Sizing in the Tibial Arteries
University Hospitals Cleveland Medical Center
NCT04748965
PROMISE I Early Feasibility Trial of the LimFlow Stent Graft System
LimFlow
NCT03124875
ALD-301 for Critical Limb Ischemia, Randomized Trial
Aldagen
NCT00392509
Safety Study of Gene Therapy in Treating Critical Leg Ischemia
Helixmith Co.
NCT00696124
Safety Study of UT-15C SR (Oral Treprostinil) in Patients Undergoing a Lower Limb Endovascular Procedure
Ochsner Health System
NCT00651885
Use of Autologous Concentrated Bone Marrow Aspirate in Preventing Wound Complications in Below Knee Amputation (BKA)
Michael Murphy
NCT02863926
BOLD MRI as a Surrogate of Improved Muscle Oxygenation Following Endovascular Therapy for the Treatment of CLI
Zimmer Biomet
NCT02601430
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 1 |
| Phase 3 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Critical Limb Ischemia right now
8 recruiting of 19 indexed (42% open).
Phase mix: 3 late (III/IV) vs 6 early (I/II) (early-phase heavy).
Top sponsor: LimFlow (2 trials), 9 others listed. 19 shown below, recruiting first. #903 of 28,963 conditions by registered trial count.
Why a small condition index still matters
Thin indexes still surface the registry rows that exist for this label. Counts stay small when ClinicalTrials.gov lists few studies under the condition string, not because this page omits rows. Verify any enrollment decision on ClinicalTrials.gov and with a clinician.
Frequently Asked Questions
How many clinical trials are there for Critical Limb Ischemia?
PlainTrial tracks 19 US clinical trials for Critical Limb Ischemia, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Critical Limb Ischemia?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.