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NCT07424014 · ClinicalTrials.gov registry record · Phase 4
The Role of Heliox in Respiratory Control
A Phase 4 study of Work of Breathing, sponsored by Indiana University.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT07424014 is a Phase 4 study of Work of Breathing that is actively recruiting participants, run by Indiana University. The registered enrollment target is 15 participants. The trial reports 1 study location across 1 state.
The verdict
NCT07424014, a Phase 4 study of Work of Breathing, is actively recruiting participants, sponsored by Indiana University.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing apparatuses. Elevated WOB increases the perception of breathing difficulty (dyspnea) and has been associated with impaired cognitive performance, including slower reaction time and reduced accuracy during attention-demanding tasks. These effects are particularly concerning in operational settings that require rapid decision-making and precise motor responses. Despite growing recognition of this issue, critical gaps remain regarding strategies to mitigate the perceptual and cognitive consequences of elevated inspiratory resistance, especially under realistic operational stressors. The objective of this study is to determine whether reducing mechanical WOB alters breathing perception and cognitive performance during inspiratory resistance. Participants will breathe either normal-density air or a low-density helium-oxygen gas mixture (heliox) to determine whether reducing mechanical WOB lowers perceived breathing effort and improves cognitive function.
Conditions Studied
Interventions
- DRUG Heliox inspirate
Study Locations (1)
Indiana
- Multidisciplinary Engineering and Sciences Hall (MESH) - Bloomington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2026-02-03 |
| Est. Completion | 2027-05-31 |
| Phase | Phase 4 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07424014
The ClinicalTrials.gov registry entry for NCT07424014 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Indiana University, which has 890 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Work of Breathing appearing as the primary indexed condition, and to 1 intervention - of which Heliox inspirate is the first listed.
NCT07424014 reports 1 study location spanning 1 distinct geographic area - top geographies include Indiana.
Frequently Asked Questions
What is clinical trial NCT07424014 about?
NCT07424014 is a clinical study titled "The Role of Heliox in Respiratory Control". Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing apparatuses. Elevated WOB increases the perception of breathing difficulty (dys...
What is the current status of trial NCT07424014?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 15 participants. The study started on 2026-02-03. Estimated completion is 2027-05-31.
What conditions does trial NCT07424014 study?
This clinical trial studies the following conditions: Work of Breathing.
What interventions are being tested in trial NCT07424014?
The interventions under investigation include: Heliox inspirate (DRUG).
Who is sponsoring clinical trial NCT07424014?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07424014 being conducted?
This trial has 1 study location across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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