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NCT07424014 · ClinicalTrials.gov registry record · Phase 4
The Role of Heliox in Respiratory Control
A Phase 4 study of Work of Breathing, sponsored by Indiana University.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT07424014: Recruiting Phase 4 study of Work of Breathing, sponsored by Indiana University.
NCT07424014 is a Phase 4 study of Work of Breathing that is actively recruiting participants, run by Indiana University. The registered enrollment target is 15 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07424014, a Phase 4 study of Work of Breathing, is actively recruiting participants, sponsored by Indiana University.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing apparatuses. Elevated WOB increases the perception of breathing difficulty (dyspnea) and has been associated with impaired cognitive performance, including slower reaction time and reduced accuracy during attention-demanding tasks. These effects are particularly concerning in operational settings that require rapid decision-making and precise motor responses. Despite growing recognition of this issue, critical gaps remain regarding strategies to mitigate the perceptual and cognitive consequences of elevated inspiratory resistance, especially under realistic operational stressors. The objective of this study is to determine whether reducing mechanical WOB alters breathing perception and cognitive performance during inspiratory resistance. Participants will breathe either normal-density air or a low-density helium-oxygen gas mixture (heliox) to determine whether reducing mechanical WOB lowers perceived breathing effort and improves cognitive function.
Primary Outcome
Time performance on the Stroop Color-Word Test (min:sec) will be measured every 10 minutes during each breathing task.
Conditions Studied
Interventions
- DRUG Heliox inspirate
Study Locations (1)
Indiana
- Multidisciplinary Engineering and Sciences Hall (MESH) - Bloomington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2026-02-03 |
| Est. Completion | 2027-05-31 |
| Phase | Phase 4 |
What NCT07424014 shows while recruiting
NCT07424014 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Work of Breathing appearing as the primary indexed condition, and to 1 intervention - of which Heliox inspirate is the first listed.
NCT07424014 reports a single indexed study location in Indiana.
Frequently Asked Questions
What is clinical trial NCT07424014 about?
NCT07424014 is a clinical study titled "The Role of Heliox in Respiratory Control". Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing apparatuses. Elevated WOB increases the perception of breathing difficulty (dys...
What is the current status of trial NCT07424014?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 15 participants. The study started on 2026-02-03. Estimated completion is 2027-05-31.
What conditions does trial NCT07424014 study?
This clinical trial studies the following conditions: Work of Breathing.
What interventions are being tested in trial NCT07424014?
The interventions under investigation include: Heliox inspirate (DRUG).
Who is sponsoring clinical trial NCT07424014?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07424014 being conducted?
This trial has 1 study location across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Work of Breathing
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07424014's enrollment target sits among peer trials
15 1881st of 2000 higher than 100 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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