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A Study to Evaluate the Safety, Tolerability, and Efficacy of Pumitamig Alone or in Combination With Ipilimumab or Cabozantinib in Participants With Advanced Renal Cell Carcinoma (RCC) (ROSETTA RCC-208)
NCT07293351 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to evaluate the safety, tolerability, and efficacy of Pumitamig alone or in combination with Ipilimumab or Cabozantinib in participants with advanced Renal Cell Carcinoma (RCC)
Conditions Studied
Interventions
- DRUG Nivolumab
- DRUG Ipilimumab
- DRUG Pumitamig
- DRUG Cabozantinib
Study Locations (20)
Other
- Local Institution - 0154 — Buenos Aires
- Local Institution - 0156 — Buenos Aires
- Local Institution - 0003 — Malvern
South Carolina
- Local Institution - 0165 — Charleston
- Carolina Urologic Research Center, LLC — Myrtle Beach
New South Wales
- Local Institution - 0076 — North Ryde
- Local Institution - 0111 — St Leonards
Connecticut
- Local Institution - 0117 — New Haven
District of Columbia
- Local Institution - 0134 — Washington D.C.
Florida
- Local Institution - 0126 — Orlando
Iowa
- Local Institution - 0124 — Iowa City
Maryland
- Local Institution - 0123 — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 234 participants |
| Start Date | 2026-03-26 |
| Est. Completion | 2031-11-26 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07293351
The ClinicalTrials.gov registry entry for NCT07293351 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 234 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bristol-Myers Squibb, which has 504 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Advanced Renal Cell Carcinoma (RCC) appearing as the primary indexed condition, and to 4 interventions — of which Nivolumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07293351 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Other, South Carolina, New South Wales. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07293351 about?
NCT07293351 is a clinical study titled "A Study to Evaluate the Safety, Tolerability, and Efficacy of Pumitamig Alone or in Combination With Ipilimumab or Cabozantinib in Participants With Advanced Renal Cell Carcinoma (RCC) (ROSETTA RCC-208)". The purpose of this study is to evaluate the safety, tolerability, and efficacy of Pumitamig alone or in combination with Ipilimumab or Cabozantinib in participants with advanced Renal Cell Carcinoma (RCC)
What is the current status of trial NCT07293351?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 234 participants. The study started on 2026-03-26. Estimated completion is 2031-11-26.
What conditions does trial NCT07293351 study?
This clinical trial studies the following conditions: Advanced Renal Cell Carcinoma (RCC). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07293351?
The interventions under investigation include: Nivolumab (DRUG), Ipilimumab (DRUG), Pumitamig (DRUG), Cabozantinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07293351?
This trial is sponsored by Bristol-Myers Squibb, which has 504 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07293351 being conducted?
This trial has 20 study locations across Connecticut, District of Columbia, Florida, Iowa, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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