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ACTIVE NOT RECRUITING Phase 1

Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Isatuximab in Participants With RRMM

NCT07217184 · View on ClinicalTrials.gov ↗

Study Summary

The primary purpose is to determine the safety and tolerability of belantamab mafodotin in combination with isatuximab, and to establish the recommended Phase 2 dose (RP2D) for the combination treatment to explore in the cohort expansion (CE) phase in participants with RRMM. This study is a sub study of the Master protocol (NCT04126200).

Conditions Studied

Interventions

  • DRUG Belantamab mafodotin
  • DRUG Isatuximab

Study Locations (19)

Other

  • GSK Investigational Site — São Paulo
  • GSK Investigational Site — Villejuif
  • GSK Investigational Site — Athens
  • GSK Investigational Site — Mexico City
  • GSK Investigational Site — Oslo
  • GSK Investigational Site — Seoul
  • GSK Investigational Site — Seoul
  • GSK Investigational Site — Ulsan
  • GSK Investigational Site — Madrid
  • GSK Investigational Site — Madrid
  • GSK Investigational Site — Pozuelo de AlarcOn Madr
  • GSK Investigational Site — Falun

Georgia

  • GSK Investigational Site — Atlanta

Massachusetts

  • GSK Investigational Site — Boston

Michigan

  • GSK Investigational Site — Grand Rapids

Wisconsin

  • GSK Investigational Site — Madison

Victoria

  • GSK Investigational Site — Fitzroy

Estado de Bahia

  • GSK Investigational Site — Salvador

Ontario

  • GSK Investigational Site — Toronto

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2021-07-29
Est. Completion 2027-03-11
Phase Phase 1

Sponsor

GlaxoSmithKline

558 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07217184

The ClinicalTrials.gov registry entry for NCT07217184 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GlaxoSmithKline, which has 558 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 2 interventions — of which Belantamab mafodotin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07217184 reports 19 study locations spanning 8 distinct geographic areas — top geographies include Other, Georgia, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07217184 about?

NCT07217184 is a clinical study titled "Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Isatuximab in Participants With RRMM". The primary purpose is to determine the safety and tolerability of belantamab mafodotin in combination with isatuximab, and to establish the recommended Phase 2 dose (RP2D) for the combination treatment to explore in the cohort expansion (CE) phase in participants with RRMM. This study is a sub stud...

What is the current status of trial NCT07217184?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2021-07-29. Estimated completion is 2027-03-11.

What conditions does trial NCT07217184 study?

This clinical trial studies the following conditions: Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07217184?

The interventions under investigation include: Belantamab mafodotin (DRUG), Isatuximab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07217184?

This trial is sponsored by GlaxoSmithKline, which has 558 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07217184 being conducted?

This trial has 19 study locations across Georgia, Massachusetts, Michigan, Wisconsin, Victoria. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial