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RECRUITING Phase 1

TLN-372 in Advanced KRAS Mutant Solid Tumors

NCT07204340 · View on ClinicalTrials.gov ↗

Study Summary

The primary purpose of this study is to evaluate the safety, pharmacokinetics, and anti-tumor activity of TLN-372 as a single agent and in combination with other anti-tumor agents, in patients with advanced KRAS mutant solid tumors

Conditions Studied

Interventions

  • DRUG TLN-372
  • DRUG TLN-372 in combination with cetuximab
  • DRUG TLN-372 in combination with pembrolizumab

Study Locations (10)

Alabama

  • University of Alabama at Birmingham — Birmingham

Massachusetts

  • Dana-Farber Cancer Institute — Boston

Michigan

  • START Midwest — Grand Rapids

Missouri

  • Washington University Medical Campus — St Louis

New York

  • Memorial Sloan Kettering Cancer Center — New York

Tennessee

  • Sarah Cannon Research Institute — Nashville

Victoria

  • Peter MacCallum Cancer Centre — Melbourne

Western Australia

  • Linear Clinical Research — Perth

Trial Details

FieldValue
Enrollment Target 240 participants
Start Date 2025-09-29
Est. Completion 2032-04-01
Phase Phase 1

Sponsor

Treeline Biosciences

34 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07204340

The ClinicalTrials.gov registry entry for NCT07204340 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Treeline Biosciences, which has 34 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with KRAS Mutant Solid Tumors appearing as the primary indexed condition, and to 3 interventions — of which TLN-372 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07204340 reports 10 study locations spanning 10 distinct geographic areas — top geographies include Alabama, Massachusetts, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07204340 about?

NCT07204340 is a clinical study titled "TLN-372 in Advanced KRAS Mutant Solid Tumors". The primary purpose of this study is to evaluate the safety, pharmacokinetics, and anti-tumor activity of TLN-372 as a single agent and in combination with other anti-tumor agents, in patients with advanced KRAS mutant solid tumors

What is the current status of trial NCT07204340?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 240 participants. The study started on 2025-09-29. Estimated completion is 2032-04-01.

What conditions does trial NCT07204340 study?

This clinical trial studies the following conditions: KRAS Mutant Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07204340?

The interventions under investigation include: TLN-372 (DRUG), TLN-372 in combination with cetuximab (DRUG), TLN-372 in combination with pembrolizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07204340?

This trial is sponsored by Treeline Biosciences, which has 34 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07204340 being conducted?

This trial has 10 study locations across Alabama, Massachusetts, Michigan, Missouri, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial