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RECRUITING Phase 2

A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan

NCT07196644 · View on ClinicalTrials.gov ↗

Study Summary

Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess adverse events and change in disease activity of telisotuzumab adizutecan. Telisotuzumab adizutecan is an investigational drug being developed for the treatment of locally advanced or metastatic solid tumors that harbor MET amplification. This study will have 1 arm where participants will receive telisotuzumab adizutecan. Approximately 125 participants 12 years of age or older. with solid tumors harboring MET amplification will be enrolled in the study in up to 55 sites around the world. Participants will receive intravenous (IV) telisotuzumab adizutecan, as part of the 61.5 month study duration. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.

Interventions

  • DRUG Telisotuzumab Adizutecan

Study Locations (20)

California

  • City of Hope National Medical Center /ID# 275613 — Duarte
  • Valkyrie Clinical Trials /ID# 275547 — Los Angeles

Illinois

  • Northwestern University Feinberg School of Medicine /ID# 276436 — Chicago
  • University of Chicago Medical Center /ID# 275342 — Chicago

Texas

  • The University of Texas MD Anderson Cancer Center /ID# 275663 — Houston
  • South Texas Accelerated Research Therapeutics (START) /ID# 276608 — San Antonio

Tel Aviv

  • The Chaim Sheba Medical Center /ID# 274342 — Ramat Gan
  • Tel Aviv Sourasky Medical Center /ID# 274344 — Tel Aviv

Other

  • Hadassah Medical Center-Hebrew University /ID# 274343 — Jerusalem
  • Rabin Medical Center. /ID# 274341 — Petah Tikva

Connecticut

  • Yale University School of Medicine /ID# 275978 — New Haven

Florida

  • Florida Cancer Specialists - North /ID# 277137 — St. Petersburg

Michigan

  • START Midwest /ID# 276603 — Grand Rapids

Trial Details

FieldValue
Enrollment Target 125 participants
Start Date 2025-10-29
Est. Completion 2030-12
Phase Phase 2

Sponsor

AbbVie

603 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07196644

The ClinicalTrials.gov registry entry for NCT07196644 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 125 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AbbVie, which has 603 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Solid Tumors Harboring MET Amplification appearing as the primary indexed condition, and to 1 intervention — of which Telisotuzumab Adizutecan is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07196644 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, Illinois, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07196644 about?

NCT07196644 is a clinical study titled "A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan". Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess adverse events and change in disease activity of telisotuzumab adizutecan. Telisotuzumab adizutecan is an investigational drug being developed for the treatment of ...

What is the current status of trial NCT07196644?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 125 participants. The study started on 2025-10-29. Estimated completion is 2030-12.

What conditions does trial NCT07196644 study?

This clinical trial studies the following conditions: Solid Tumors Harboring MET Amplification. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07196644?

The interventions under investigation include: Telisotuzumab Adizutecan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07196644?

This trial is sponsored by AbbVie, which has 603 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07196644 being conducted?

This trial has 20 study locations across California, Connecticut, Florida, Illinois, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial