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NCT07185724 · ClinicalTrials.gov registry record · Phase 4
Ketorolac Use and Fresh Embryo Transfer Outcomes
A Phase 4 study of Infertility (IVF Patients) and Post-op Pain, sponsored by Jessica D. Kresowik.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 200
- Enrollment target
- 1
- Study location
NCT07185724 is a Phase 4 study of Infertility (IVF Patients) and Post-op Pain that is actively recruiting participants, run by Jessica D. Kresowik. The registered enrollment target is 200 participants, below the 457-participant average among 9 other Infertility (IVF Patients) trials with a reported enrollment target (56% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07185724, a Phase 4 study of Infertility (IVF Patients) and Post-op Pain, is actively recruiting participants, sponsored by Jessica D. Kresowik.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
Ketorolac is a medication often used to relieve pain after surgery. In the past, infertility doctors have been cautious about using ketorolac after egg retrieval for patients planning a fresh embryo transfer (usually done 5 days later). The concern was that ketorolac might increase the risk of bleeding or reduce the chances of the embryo implanting in the uterus. This concern comes from how ketorolac works-it blocks certain chemicals in the body (like prostaglandins and thromboxane) that help with blood clotting and play a role in early pregnancy. However, a large review of past studies found no real evidence that ketorolac increases bleeding risk. In fact, ketorolac is now routinely used for pain relief in IVF cycles where embryos are frozen and not transferred right away. More recent studies from Boston and Chapel Hill have shown that ketorolac provides better pain control and does not appear to harm IVF outcomes, even when embryos are transferred fresh (within the same cycle). Despite these encouraging findings, many IVF clinics still avoid using ketorolac during fresh cycles because of the theoretical concerns. That's why we need stronger, higher-quality research. This study aims to fill that gap by conducting a double-blind randomized controlled trial to find out whether giving ketorolac through an IV after egg retrieval affects important IVF outcomes-especially the chance of implantation and live birth-in patients undergoing fresh embryo transfers. Patients who choose to join the study will randomly be placed into one of two groups. One group will get ketorolac (a pain medicine) after an IVF egg retrieval. The other group will not get ketorolac after egg retrieval. Everything else in their IVF care will stay the same as it normally would. Primary outcome will be implantation rate following fresh embryo transfers in patients receiving ketorolac (30mg IV) vs no ketorolac for post-retrieval analgesia. Secondary outcomes will include pain scale, narcotics req
Conditions Studied
Interventions
- DRUG Ketorolac 30 mg IV
Study Locations (1)
Iowa
- UI Health Care Center for Advanced Reproductive Care - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2025-11-08 |
| Est. Completion | 2028-09-01 |
| Phase | Phase 4 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07185724
The ClinicalTrials.gov registry entry for NCT07185724 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 457-participant average among 9 other Infertility (IVF Patients) trials with a reported enrollment target (56% lower). The listed sponsor is Jessica D. Kresowik, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 5 conditions, with Infertility (IVF Patients) appearing as the primary indexed condition, and to 1 intervention - of which Ketorolac 30 mg IV is the first listed.
NCT07185724 reports 1 study location spanning 1 distinct geographic area - top geographies include Iowa.
Frequently Asked Questions
What is clinical trial NCT07185724 about?
NCT07185724 is a clinical study titled "Ketorolac Use and Fresh Embryo Transfer Outcomes". Ketorolac is a medication often used to relieve pain after surgery. In the past, infertility doctors have been cautious about using ketorolac after egg retrieval for patients planning a fresh embryo transfer (usually done 5 days later). The concern was that ketorolac might increase the risk of bleed...
What is the current status of trial NCT07185724?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 200 participants. The study started on 2025-11-08. Estimated completion is 2028-09-01.
What conditions does trial NCT07185724 study?
This clinical trial studies the following conditions: Infertility (IVF Patients), Post-op Pain, Infertility Treatment, Fresh Embryo Transfer, Oocyte Retrieval and Post Operative Pain Control.
What interventions are being tested in trial NCT07185724?
The interventions under investigation include: Ketorolac 30 mg IV (DRUG).
Who is sponsoring clinical trial NCT07185724?
This trial is sponsored by Jessica D. Kresowik, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07185724 being conducted?
This trial has 1 study location across Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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