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ACTIVE NOT RECRUITING Phase 2

Aleniglipron Phase 2 Body Composition Study

NCT07169942 · View on ClinicalTrials.gov ↗

Study Summary

This is a randomized, double-blind, placebo-controlled study evaluating the effects of aleniglipron on body composition in participants living with obesity. Participants will be randomized to aleniglipron or placebo in a ratio of 5:1. Participants will receive multiple ascending QD doses of aleniglipron or placebo in titration steps of 4 weeks duration for a total of 40 weeks of treatment.

Interventions

  • DRUG aleniglipron or placebo

Study Locations (11)

South Carolina

  • Research Site — Moncks Corner
  • Research Site — North Charleston

Texas

  • Research Site — Austin
  • Research Site — San Antonio

Arizona

  • Research Site — Phoenix

Illinois

  • Research Site — Chicago

Minnesota

  • Research Site — Richfield

Missouri

  • Research Site — City of Saint Peters

New York

  • Research Site — Rochester

North Carolina

  • Research Site — Wilmington

Trial Details

FieldValue
Enrollment Target 71 participants
Start Date 2025-08-15
Est. Completion 2026-10
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07169942

The ClinicalTrials.gov registry entry for NCT07169942 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 71 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics, which has 4 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Obesity, Overweight, or Chronic Weight Management appearing as the primary indexed condition, and to 1 intervention — of which aleniglipron or placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07169942 reports 11 study locations spanning 9 distinct geographic areas — top geographies include South Carolina, Texas, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07169942 about?

NCT07169942 is a clinical study titled "Aleniglipron Phase 2 Body Composition Study". This is a randomized, double-blind, placebo-controlled study evaluating the effects of aleniglipron on body composition in participants living with obesity. Participants will be randomized to aleniglipron or placebo in a ratio of 5:1. Participants will receive multiple ascending QD doses of alenigli...

What is the current status of trial NCT07169942?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 71 participants. The study started on 2025-08-15. Estimated completion is 2026-10.

What conditions does trial NCT07169942 study?

This clinical trial studies the following conditions: Obesity, Overweight, or Chronic Weight Management. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07169942?

The interventions under investigation include: aleniglipron or placebo (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07169942?

This trial is sponsored by Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics, which has 4 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07169942 being conducted?

This trial has 11 study locations across Arizona, Illinois, Minnesota, Missouri, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial