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RECRUITING Phase 1

Actinium Therapy for Late-stage Aggressive Sarcomas

NCT07156565 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this clinical trial is to learn about the safety of drug \[Ac225\]RTX-2358 and the diagnostic imaging agent \[Cu64\]LNTH-1363S. Additionally Ratio Therapeutics will learn if \[Ac225\]RTX-2358 drug is effective in treating advanced sarcoma. The main questions the study aims to answer in Phase/Part 1 of the trial are: * Is \[Ac225\]RTX-2358 tolerable or does it cause toxicities (medical problems) in patients. * What is the most tolerable dose of \[Ac225\]RTX-2358 * Does the treatment show effectiveness on advanced sarcoma Participants will: * Take drug \[Ac225\]RTX-2358 once every 8 weeks (4 cycle target; 6 cycle maximum) over a period of 12 months * Visit the clinic three times for the first week of cycle one, then once a week for the remaining 7 weeks of cycle 1 for check-ups and tests. * For cycles 2-6: patient will visit the clinic once every 2 weeks for checkups and tests * Remain in long term follow-up for a period of four additional years

Interventions

  • DRUG [Ac 225]RTX-2358
  • DIAGNOSTIC_TEST [Cu64]LNTH-1363S

Study Locations (6)

California

  • UCLA — Los Angeles

Minnesota

  • Mayo Clinic — Rochester

New York

  • Memorial Sloane Kettering Cancer Center — New York

Ohio

  • Case Western — Cleveland

Texas

  • MD Anderson Cancer Center — Houston

Ontario

  • Princess Margaret Cancer Centre — Toronto

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2025-11-12
Est. Completion 2032-01
Phase Phase 1

Sponsor

Ratio Therapeutics

28 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07156565

The ClinicalTrials.gov registry entry for NCT07156565 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ratio Therapeutics, which has 28 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced Soft Tissue Sarcoma appearing as the primary indexed condition, and to 2 interventions — of which [Ac 225]RTX-2358 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07156565 reports 6 study locations spanning 6 distinct geographic areas — top geographies include California, Minnesota, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07156565 about?

NCT07156565 is a clinical study titled "Actinium Therapy for Late-stage Aggressive Sarcomas". The goal of this clinical trial is to learn about the safety of drug \[Ac225\]RTX-2358 and the diagnostic imaging agent \[Cu64\]LNTH-1363S. Additionally Ratio Therapeutics will learn if \[Ac225\]RTX-2358 drug is effective in treating advanced sarcoma. The main questions the study aims to answer in ...

What is the current status of trial NCT07156565?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2025-11-12. Estimated completion is 2032-01.

What conditions does trial NCT07156565 study?

This clinical trial studies the following conditions: Advanced Soft Tissue Sarcoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07156565?

The interventions under investigation include: [Ac 225]RTX-2358 (DRUG), [Cu64]LNTH-1363S (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07156565?

This trial is sponsored by Ratio Therapeutics, which has 28 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07156565 being conducted?

This trial has 6 study locations across California, Minnesota, New York, Ohio, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial