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RECRUITING Phase 3

OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity

NCT07140783 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this clinical trial is to learn if Phentolamine Ophthalmic Solution works to treat adults that have had keratorefractive surgery and have decreased visual acuity under mesopic conditions. It will also learn about the safety of Phentolamine Ophthalmic Solution. The main questions it aims to answer are: Researchers will compare Phentolamine Ophthalmic Solution to a placebo (a look-alike substance that contains no drug) to see if Phentolamine Ophthalmic Solution works to improve vision in low light conditions. Participants will: Take Phentolamine Ophthalmic Solution or a placebo drop every day for 2 weeks Visit the clinic once every week for 2 weeks for checkups and tests Keep a diary of when they instill the study medication each evening

Interventions

  • DRUG Placebo
  • DRUG 0.75% Phentolamine Ophthalmic Solution

Study Locations (20)

California

  • Global Research Management — Glendale
  • Gordon Schanzlin New Vision — La Jolla
  • Eye Research Foundation — Newport Beach
  • California Eye Specialists Medical Group — Pasadena
  • NVISION Clinical Research — San Diego
  • Scripps Poway Eyecare and Optometry — San Diego
  • Wolsten and Goldberg Eye Assoc. — Torrance

Arizona

  • Arizona Eye Care — Chandler
  • Carrot Eye Center — Mesa
  • Eye Doctors of Arizona — Phoenix
  • MRB Eye Care Consultants — Scottsdale

Florida

  • Glaucoma Specialist of South Florida — Delray Beach
  • Segal Drug Trials — Delray Beach

Illinois

  • Wyse Eyecare — Northbrook
  • Virdi Eye Clinic — Rock Island

Kansas

  • Durrie Vision — Overland Park
  • Kannarr Eye Care — Pittsburg

Massachusetts

  • Eye Health Vision Center — South Dartmouth
  • Northeast Eye Research Associates — Woburn

North Carolina

  • Oculus Research — Garner

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2025-09-02
Est. Completion 2026-03
Phase Phase 3

Sponsor

Ocuphire Pharma

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07140783

The ClinicalTrials.gov registry entry for NCT07140783 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ocuphire Pharma, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Vision Disorders appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07140783 reports 20 study locations spanning 7 distinct geographic areas — top geographies include California, Arizona, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07140783 about?

NCT07140783 is a clinical study titled "OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity". The goal of this clinical trial is to learn if Phentolamine Ophthalmic Solution works to treat adults that have had keratorefractive surgery and have decreased visual acuity under mesopic conditions. It will also learn about the safety of Phentolamine Ophthalmic Solution. The main questions it aims ...

What is the current status of trial NCT07140783?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 200 participants. The study started on 2025-09-02. Estimated completion is 2026-03.

What conditions does trial NCT07140783 study?

This clinical trial studies the following conditions: Vision Disorders, Vision Loss Night. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07140783?

The interventions under investigation include: Placebo (DRUG), 0.75% Phentolamine Ophthalmic Solution (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07140783?

This trial is sponsored by Ocuphire Pharma, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07140783 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Illinois, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial