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NCT07120386 · ClinicalTrials.gov registry record · NA
Irrigating vs Traditional Negative Pressure Wound Therapy to Treat Necrotizing Soft Tissue Infections
A NA study of Necrotizing Soft Tissue Infections, sponsored by HealthPartners Institute.
- Recruiting
- Registry status
- NA
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT07120386: Recruiting NA study of Necrotizing Soft Tissue Infections, sponsored by HealthPartners Institute.
NCT07120386 is a NA study of Necrotizing Soft Tissue Infections that is actively recruiting participants, run by HealthPartners Institute. The registered enrollment target is 30 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07120386, a NA study of Necrotizing Soft Tissue Infections, is actively recruiting participants, sponsored by HealthPartners Institute.
- RECRUITING
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
Necrotizing Soft Tissue Infections (NSTIs) are rapidly progressing infections that have a high morbidity and mortality, with the greatest morbidity related to managing the large wounds required to treat these patients. Initial treatment requires wide surgical removal of infected tissue and optimal management is essential to reducing morbidity in these patients. Negative pressure wound therapy (NPWT) is a widely used technology that has revolutionized wound management. NPWT is utilized across the spectrum of acute wounds, including routine postoperative incision management, traumatic wounds, and wounds related to surgical debridement of NSTIs which are frequently some of the most complicated of wounds encountered. Most NSTI cases at Regions Hospital currently utilize negative pressure wound therapy with instillation (NPWTi) where the wound is irrigated to clean out debris. Currently, there is a paucity of data comparing traditional NPWT and NPWTi and the choice of which device to use is left to surgeon discretion. This study is a first step at identifying the effects of NPWTi compared to NPWT alone on the care of NSTI patients. If the theoretical benefits of NPWTi over NPWT translate to practice, those treated with NPWTi would be expected to have a reduced rate of hospital readmission after their index hospitalization in addition to shorter time to definitive closure/coverage. This is a pilot study to assess the feasibility of enrolling patients with NSTIs in a randomized controlled trial to assess outcomes between the two devices.
Primary Outcome
Did the patient have an unplanned readmission to the hospital (Y/N) within 30 days of discharge
Conditions Studied
Interventions
- DEVICE Negative Pressure Wound Therapy
- DEVICE Negative Pressure Wound Therapy with Instillation
Study Locations (1)
Minnesota
- Regions Hospital - Saint Paul
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2025-08-01 |
| Est. Completion | 2026-10 |
| Phase | NA |
What NCT07120386 shows while recruiting
NCT07120386 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Necrotizing Soft Tissue Infections appearing as the primary indexed condition, and to 2 interventions - of which Negative Pressure Wound Therapy is the first listed.
NCT07120386 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT07120386 about?
NCT07120386 is a clinical study titled "Irrigating vs Traditional Negative Pressure Wound Therapy to Treat Necrotizing Soft Tissue Infections". Necrotizing Soft Tissue Infections (NSTIs) are rapidly progressing infections that have a high morbidity and mortality, with the greatest morbidity related to managing the large wounds required to treat these patients. Initial treatment requires wide surgical removal of infected tissue and optimal m...
What is the current status of trial NCT07120386?
This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2025-08-01. Estimated completion is 2026-10.
What conditions does trial NCT07120386 study?
This clinical trial studies the following conditions: Necrotizing Soft Tissue Infections.
What interventions are being tested in trial NCT07120386?
The interventions under investigation include: Negative Pressure Wound Therapy (DEVICE), Negative Pressure Wound Therapy with Instillation (DEVICE).
Who is sponsoring clinical trial NCT07120386?
This trial is sponsored by HealthPartners Institute, which has 146 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07120386 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07120386's enrollment target sits among peer trials
30 1593rd of 2000 higher than 299 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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