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A Study to Learn About How a New Pneumococcal Vaccine Works in Adults
NCT07086677 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to learn about the safety and tolerability of a pneumococcal vaccine in adults. Participants will receive either: * an experimental PG4 vaccine * a PG4 vaccine comparator * a standard 20vPnC vaccine comparator * placebo. A placebo does not have any medicine in it but looks just like the study medicine. Participants will take part in this study for up to 18 months depending on which group they are assigned to. During this time, the participants will receive up to two doses of study vaccine or comparator and take part in follow-up visits. At these clinic visits, participants will be asked if any side effects were experienced. The participants will also have to give blood samples during clinic visits.
Conditions Studied
Interventions
- BIOLOGICAL PG4 vaccine in Buffer 1 with low dose PA-001
- BIOLOGICAL PG4 in Buffer 1 with low dose PA-002
- BIOLOGICAL PG4 in Buffer 1 with high dose PA-001
- BIOLOGICAL PG4 vaccine in Buffer 1 with high dose PA-002
- BIOLOGICAL PG4 vaccine in Buffer 2
Study Locations (5)
California
- Orange County Research Center — Lake Forest
Florida
- Indago Research & Health Center, Inc — Hialeah
Kansas
- Johnson County Clinical Trials — Lenexa
Nebraska
- Velocity Clinical Research, Omaha — Omaha
Ohio
- CTI Clinical Research Center — Cincinnati
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 372 participants |
| Start Date | 2025-07-22 |
| Est. Completion | 2027-09-23 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07086677
The ClinicalTrials.gov registry entry for NCT07086677 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 372 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Streptococcus Pneumoniae appearing as the primary indexed condition, and to 5 interventions — of which PG4 vaccine in Buffer 1 with low dose PA-001 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07086677 reports 5 study locations spanning 5 distinct geographic areas — top geographies include California, Florida, Kansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07086677 about?
NCT07086677 is a clinical study titled "A Study to Learn About How a New Pneumococcal Vaccine Works in Adults". The purpose of this study is to learn about the safety and tolerability of a pneumococcal vaccine in adults. Participants will receive either: * an experimental PG4 vaccine * a PG4 vaccine comparator * a standard 20vPnC vaccine comparator * placebo. A placebo does not have any medicine in it but l...
What is the current status of trial NCT07086677?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 372 participants. The study started on 2025-07-22. Estimated completion is 2027-09-23.
What conditions does trial NCT07086677 study?
This clinical trial studies the following conditions: Streptococcus Pneumoniae. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07086677?
The interventions under investigation include: PG4 vaccine in Buffer 1 with low dose PA-001 (BIOLOGICAL), PG4 in Buffer 1 with low dose PA-002 (BIOLOGICAL), PG4 in Buffer 1 with high dose PA-001 (BIOLOGICAL), PG4 vaccine in Buffer 1 with high dose PA-002 (BIOLOGICAL), PG4 vaccine in Buffer 2 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07086677?
This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07086677 being conducted?
This trial has 5 study locations across California, Florida, Kansas, Nebraska, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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