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ACTIVE NOT RECRUITING Phase 3

A Study Comparing Zasocitinib (TAK-279) With Deucravacitinib in Adults With Plaque Psoriasis

NCT06973291 · View on ClinicalTrials.gov ↗

Study Summary

The main aim of this study is to assess whether zasocitinib works better than deucravacitinib in treating participants with moderate-to-severe plaque psoriasis. Participants will take one tablet daily of either zasocitinib or a matching placebo, along with one capsule daily of either over-encapsulated deucravacitinib or a matching placebo, for a duration of 16 weeks. Participants will be in the study for up to 25 weeks, which includes screening period of up to 35 days, a 16-week treatment period, and a 4-week safety follow-up period.

Conditions Studied

Interventions

  • DRUG Deucravacitinib
  • DRUG Zasocitinib
  • DRUG Placebo to match zasocitinib
  • DRUG Placebo to match deucravacitinib

Study Locations (20)

California

  • Zenith Research, Inc. — Beverly Hills
  • First OC Dermatology Research Inc. — Fountain Valley
  • UNISON Clinical Trials (Shahram Jacobs md inc.) — Sherman Oaks

Florida

  • Direct Helpers Research Center — Hialeah
  • San Marcus Research Clinic Inc — Miami Lakes
  • Advanced Clinical Research Institute — Tampa

Arkansas

  • Johnson Dermatology — Fort Smith
  • Burke Pharmaceutical Research — Hot Springs

Connecticut

  • Central Connecticut Dermatology, PLLC — Cromwell
  • Yale University School of Medicine — New Haven

Illinois

  • Arlington Dermatology — Rolling Meadows
  • Endeavor Health Clinical Trials — Skokie

Indiana

  • Dawes Fretzin Clinical Research Group, LLC — Indianapolis

Maryland

  • Lawrence J Green, MD LLC — Rockville

Michigan

  • Henry Ford Health System — Detroit

Trial Details

FieldValue
Enrollment Target 606 participants
Start Date 2025-07-09
Est. Completion 2026-07-03
Phase Phase 3

Sponsor

Takeda

387 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06973291

The ClinicalTrials.gov registry entry for NCT06973291 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 606 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Takeda, which has 387 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Plaque Psoriasis appearing as the primary indexed condition, and to 4 interventions — of which Deucravacitinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06973291 reports 20 study locations spanning 13 distinct geographic areas — top geographies include California, Florida, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06973291 about?

NCT06973291 is a clinical study titled "A Study Comparing Zasocitinib (TAK-279) With Deucravacitinib in Adults With Plaque Psoriasis". The main aim of this study is to assess whether zasocitinib works better than deucravacitinib in treating participants with moderate-to-severe plaque psoriasis. Participants will take one tablet daily of either zasocitinib or a matching placebo, along with one capsule daily of either over-encapsula...

What is the current status of trial NCT06973291?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 606 participants. The study started on 2025-07-09. Estimated completion is 2026-07-03.

What conditions does trial NCT06973291 study?

This clinical trial studies the following conditions: Plaque Psoriasis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06973291?

The interventions under investigation include: Deucravacitinib (DRUG), Zasocitinib (DRUG), Placebo to match zasocitinib (DRUG), Placebo to match deucravacitinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06973291?

This trial is sponsored by Takeda, which has 387 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06973291 being conducted?

This trial has 20 study locations across Arkansas, California, Connecticut, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial