Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Phase 1 Study of AUTX-703 in Relapsed/Refractory AML and MDS
NCT06846606 · View on ClinicalTrials.gov ↗
Study Summary
This Phase 1, multicenter, open-label, dose escalation and dose optimization study is designed to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of AUTX-703 administered orally in subjects with advanced hematologic malignancies.
Conditions Studied
Interventions
- DRUG AUTX-703
Study Locations (9)
New York
- Roswell Park Comprehensive Cancer Center — Buffalo
- Memorial Sloan Kettering Cancer Center — New York
California
- City of Hope National Medical Center — Duarte
Florida
- H Lee Moffitt Cancer Center and Research Institute — Tampa
North Carolina
- University of North Carolina at Chapel Hill — Chapel Hill
Ohio
- Ohio State University, The James Comprehensive Cancer — Columbus
Pennsylvania
- UPENN Perelman Center for Advanced Medicine — Philadelphia
Tennessee
- Sarah Cannon Center for Blood Cancer at TriStar Centennia — Nashville
Texas
- University of Texas MD Anderson Cancer Center — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2025-05-01 |
| Est. Completion | 2028-06 |
| Phase | Phase 1 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06846606
The ClinicalTrials.gov registry entry for NCT06846606 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 34 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Auron Therapeutics, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 6 conditions, with Refractory Myelodysplastic Syndromes appearing as the primary indexed condition, and to 1 intervention — of which AUTX-703 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06846606 reports 9 study locations spanning 8 distinct geographic areas — top geographies include New York, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06846606 about?
NCT06846606 is a clinical study titled "Phase 1 Study of AUTX-703 in Relapsed/Refractory AML and MDS". This Phase 1, multicenter, open-label, dose escalation and dose optimization study is designed to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of AUTX-703 administered orally in subjects with advanced hematologic malignancies.
What is the current status of trial NCT06846606?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 34 participants. The study started on 2025-05-01. Estimated completion is 2028-06.
What conditions does trial NCT06846606 study?
This clinical trial studies the following conditions: Refractory Myelodysplastic Syndromes, Relapsed/Refractory AML, Relapsed Myelodysplastic Syndromes, Relapsed Acute Myeloid Leukemia (AML), Refractory Acute Myeloid Leukemia (AML). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06846606?
The interventions under investigation include: AUTX-703 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06846606?
This trial is sponsored by Auron Therapeutics, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06846606 being conducted?
This trial has 9 study locations across California, Florida, New York, North Carolina, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.