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RECRUITING Phase 2

Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)

NCT06814145 · View on ClinicalTrials.gov ↗

Study Summary

Researchers are looking for new ways to treat people with a type of pulmonary hypertension called combined postcapillary and precapillary pulmonary hypertension (Cpc-PH). This study focuses on Cpc-PH that is caused by heart failure with preserved ejection fraction (HFpEF). Researchers want to know if the study treatment, sotatercept, can treat people with Cpc-PH caused by HFpEF. This is an extension study, which means people who took part in a certain study on sotatercept for Cpc-PH (called a parent study) may be able to join this study. In this extension study, people will take sotatercept and researchers will follow their health for a longer time. The main goal of this extension study is to learn about the long-term safety of sotatercept and if people tolerate it over a longer period of time.

Conditions Studied

Interventions

  • BIOLOGICAL Sotatercept

Study Locations (20)

Ohio

  • The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital ( Site 1001) — Cincinnati
  • The Cleveland Clinic Foundation. ( Site 1065) — Cleveland
  • The Ohio State University Wexner Medical Center ( Site 1032) — Columbus

California

  • Jeffrey S. Sager, MD Medical Corporation ( Site 1060) — Santa Barbara
  • Stanford University Medical Center ( Site 1024) — Stanford

Pennsylvania

  • Allegheny General Hospital ( Site 1088) — Pittsburgh
  • Lankenau Medical Center ( Site 1089) — Wynnewood

Arizona

  • Pulmonary Associates, PA ( Site 1008) — Phoenix

Colorado

  • South Denver Cardiology Associates ( Site 1091) — Littleton

Connecticut

  • Yale New Haven Hospital ( Site 1093) — New Haven

Florida

  • AdventHealth Orlando ( Site 1058) — Orlando

Georgia

  • The Emory Clinic ( Site 1030) — Atlanta

Trial Details

FieldValue
Enrollment Target 130 participants
Start Date 2025-04-16
Est. Completion 2029-03-30
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06814145

The ClinicalTrials.gov registry entry for NCT06814145 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 130 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hypertension, Pulmonary appearing as the primary indexed condition, and to 1 intervention — of which Sotatercept is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06814145 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Ohio, California, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06814145 about?

NCT06814145 is a clinical study titled "Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)". Researchers are looking for new ways to treat people with a type of pulmonary hypertension called combined postcapillary and precapillary pulmonary hypertension (Cpc-PH). This study focuses on Cpc-PH that is caused by heart failure with preserved ejection fraction (HFpEF). Researchers want to know ...

What is the current status of trial NCT06814145?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 130 participants. The study started on 2025-04-16. Estimated completion is 2029-03-30.

What conditions does trial NCT06814145 study?

This clinical trial studies the following conditions: Hypertension, Pulmonary. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06814145?

The interventions under investigation include: Sotatercept (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06814145?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06814145 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial