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NCT06753916 · ClinicalTrials.gov registry record · Phase 2
ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty
A Phase 2 study of Corneal Transplant Failure, sponsored by Massachusetts Eye and Ear Infirmary.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 96
- Enrollment target
- 12
- Study locations
NCT06753916 is a Phase 2 study of Corneal Transplant Failure that is actively recruiting participants, run by Massachusetts Eye and Ear Infirmary. The registered enrollment target is 96 participants. The trial reports 12 study locations across 9 states.
The verdict
NCT06753916, a Phase 2 study of Corneal Transplant Failure, is actively recruiting participants, sponsored by Massachusetts Eye and Ear Infirmary.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 96 participants
- Enrollment target
- 12
- Study locations
Study Summary
The main objective of this study is to determine the safety of Ex Vivo Cross Linking (CXL) of donor corneal tissue in participants who have undergone high-risk penetrating keratoplasty.
Conditions Studied
Interventions
- PROCEDURE Corneal Donor Tissue with Cross Linking
- PROCEDURE Corneal Donor Tissue without Cross Linking
Study Locations (12)
California
- University of California Irvine - Gavin Herbert Eye Institute - Irvine
- The University of California Los Angeles - Doris Stein Eye Research Center - Los Angeles
- University of California San Francisco - Wayne and Gladys Valley Center for Vision - San Francisco
North Carolina
- Wake Forest Baptist Eye Center - Bermuda Run
- Duke University - Duke Eye Center - Durham
Florida
- University of Miami - Bascom Palmer Eye Institute - Miami
Indiana
- Price Vision Group - Indianapolis
Kansas
- Kansas City Eye Clinic - Overland Park
Maryland
- Mid-Atlantic Cornea Consultant - Towson
Massachusetts
- Massachusetts Eye and Ear - Boston
Michigan
- University of Michigan - Kellogg Eye Center - Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 96 participants |
| Start Date | 2025-04-01 |
| Est. Completion | 2031-01-01 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06753916
The ClinicalTrials.gov registry entry for NCT06753916 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 96 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Massachusetts Eye and Ear Infirmary, which has 73 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Corneal Transplant Failure appearing as the primary indexed condition, and to 2 interventions - of which Corneal Donor Tissue with Cross Linking is the first listed.
NCT06753916 reports 12 study locations spanning 9 distinct geographic areas - top geographies include California, North Carolina, Florida.
Frequently Asked Questions
What is clinical trial NCT06753916 about?
NCT06753916 is a clinical study titled "ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty". The main objective of this study is to determine the safety of Ex Vivo Cross Linking (CXL) of donor corneal tissue in participants who have undergone high-risk penetrating keratoplasty.
What is the current status of trial NCT06753916?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 96 participants. The study started on 2025-04-01. Estimated completion is 2031-01-01.
What conditions does trial NCT06753916 study?
This clinical trial studies the following conditions: Corneal Transplant Failure.
What interventions are being tested in trial NCT06753916?
The interventions under investigation include: Corneal Donor Tissue with Cross Linking (PROCEDURE), Corneal Donor Tissue without Cross Linking (PROCEDURE).
Who is sponsoring clinical trial NCT06753916?
This trial is sponsored by Massachusetts Eye and Ear Infirmary, which has 73 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06753916 being conducted?
This trial has 12 study locations across California, Florida, Indiana, Kansas, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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