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RECRUITING Phase 3

A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

NCT06747351 · View on ClinicalTrials.gov ↗

Study Summary

The main aim of this study is to evaluate the pharmacokinetic (PK) comparability between TAK-881 and HYQVIA subcutaneous (SC) administration for maintenance therapy of CIDP. The participants who are already receiving intravenous immunoglobulin G (IGIV), conventional subcutaneous intravenous immunoglobulin G (cIGSC), or HYQVIA will be treated with the same dose equivalent as their prior IG treatment with HYQVIA for 20 weeks followed by TAK-881 for 24 weeks. Participants will need to visit the clinic every 3 or 4 weeks until they enter the extension phase. In the extension phase, home infusions are allowed, and visits will occur between every 12 weeks and 24 weeks.

Interventions

  • BIOLOGICAL TAK-881
  • BIOLOGICAL HYQVIA
  • DEVICE SC Investigational Needle Sets

Study Locations (20)

North Carolina

  • University of North Carolina (UNC) — Chapel Hill
  • Duke University Hospital — Durham
  • Raleigh Neurology Associates — Raleigh
  • Atrium Health Wake Forest Baptist — Winston-Salem

Florida

  • Neurology Associates — Maitland
  • Knight Neurology — Rockledge

Other

  • Instituto Argentino de Investigacion Neurologica (IADIN) — Buenos Aires
  • Fakultni nemocnice Hradec Kralove — Hradec Králové

Arizona

  • HonorHealth Neurology — Scottsdale

California

  • Stanford Neuroscience Health Center — Palo Alto

Connecticut

  • Yale University School of Medicine — New Haven

Missouri

  • The Washington University — St Louis

New York

  • NYU Langone Health — New York

Trial Details

FieldValue
Enrollment Target 59 participants
Start Date 2025-05-06
Est. Completion 2028-06-25
Phase Phase 3

Sponsor

Takeda

387 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06747351

The ClinicalTrials.gov registry entry for NCT06747351 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 59 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Takeda, which has 387 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) appearing as the primary indexed condition, and to 3 interventions — of which TAK-881 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06747351 reports 20 study locations spanning 15 distinct geographic areas — top geographies include North Carolina, Florida, Other. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06747351 about?

NCT06747351 is a clinical study titled "A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)". The main aim of this study is to evaluate the pharmacokinetic (PK) comparability between TAK-881 and HYQVIA subcutaneous (SC) administration for maintenance therapy of CIDP. The participants who are already receiving intravenous immunoglobulin G (IGIV), conventional subcutaneous intravenous immunog...

What is the current status of trial NCT06747351?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 59 participants. The study started on 2025-05-06. Estimated completion is 2028-06-25.

What conditions does trial NCT06747351 study?

This clinical trial studies the following conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06747351?

The interventions under investigation include: TAK-881 (BIOLOGICAL), HYQVIA (BIOLOGICAL), SC Investigational Needle Sets (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06747351?

This trial is sponsored by Takeda, which has 387 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06747351 being conducted?

This trial has 20 study locations across Arizona, California, Connecticut, Florida, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial