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RECRUITING Phase 3

ResQ201A: Clinical Trial Of N-803 Plus TISLELIZUMAB And DOCETAXEL Versus DOCETAXEL Monotherapy In Participants With Advanced Or Metastatic Non-Small Cell Lung Cancer

NCT06745908 · View on ClinicalTrials.gov ↗

Study Summary

This is a randomized, open-label, phase 3 clinical trial to compare the efficacy and safety of N-803 plus tislelizumab and docetaxel (experimental arm) versus docetaxel monotherapy (control arm). Enrolled participants will be randomized 2:1 to treatment in the experimental arm or the control arm. Participant randomization will be stratified by geographical region (North America vs Europe vs ASIA vs Other), NSCLC histology (squamous vs nonsquamous), and actionable genomic alteration (AGA); (epidermal growth factor receptor \[EGFR\]/anaplastic lymphoma kinase \[ALK\] vs OTHER AGA vs No AGA).

Conditions Studied

Interventions

  • DRUG Docetaxel
  • DRUG Tislelizumab
  • DRUG N-803

Study Locations (17)

California

  • Chan Soon-Shiong Institute for Medicine — El Segundo
  • MemorialCare - Orange Coast Medical Center — Fountain Valley
  • OPN Healthcare INC — Glendale
  • OPN Healthcare INC/ Cancer and Blood Specialty Clinic — Los Alamitos

Florida

  • Holy Cross Hospital — Fort Lauderdale
  • The Oncology Institute of Hope and Innovation — Fort Lauderdale
  • Moffit Cancer Center — Tampa

Ohio

  • University of Cincinnati Medical Center — Cincinnati
  • University Hospitals Cleveland Medical Center — Cleveland

Tennessee

  • Tennessee Oncology — Nashville
  • Vanderbilt - Ingram Cancer Center — Nashville

Virginia

  • Virginia Cancer Specialists — Fairfax
  • Virginia Commonwealth University — Richmond

Arkansas

  • Highlands Oncology Group — Springdale

Georgia

  • Emory University - Winship Cancer Institute — Atlanta

Missouri

  • Barnes-Jewish Hospital - Siteman Cancer Center (Washington University - St. Louis) — St Louis

Trial Details

FieldValue
Enrollment Target 460 participants
Start Date 2025-10-01
Est. Completion 2029-01
Phase Phase 3

Sponsor

ImmunityBio

48 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06745908

The ClinicalTrials.gov registry entry for NCT06745908 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 460 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ImmunityBio, which has 48 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with NSCLC Stage IV appearing as the primary indexed condition, and to 3 interventions — of which Docetaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06745908 reports 17 study locations spanning 9 distinct geographic areas — top geographies include California, Florida, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06745908 about?

NCT06745908 is a clinical study titled "ResQ201A: Clinical Trial Of N-803 Plus TISLELIZUMAB And DOCETAXEL Versus DOCETAXEL Monotherapy In Participants With Advanced Or Metastatic Non-Small Cell Lung Cancer". This is a randomized, open-label, phase 3 clinical trial to compare the efficacy and safety of N-803 plus tislelizumab and docetaxel (experimental arm) versus docetaxel monotherapy (control arm). Enrolled participants will be randomized 2:1 to treatment in the experimental arm or the control arm. Pa...

What is the current status of trial NCT06745908?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 460 participants. The study started on 2025-10-01. Estimated completion is 2029-01.

What conditions does trial NCT06745908 study?

This clinical trial studies the following conditions: NSCLC Stage IV. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06745908?

The interventions under investigation include: Docetaxel (DRUG), Tislelizumab (DRUG), N-803 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06745908?

This trial is sponsored by ImmunityBio, which has 48 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06745908 being conducted?

This trial has 17 study locations across Arkansas, California, Florida, Georgia, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial