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Assessing the Relationship Between Symptoms and Mitral Regurgitnant. Severity
NCT06738615 · View on ClinicalTrials.gov ↗
Study Summary
The current American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend surgery in patient with mitral regurgitation (MR) based on 1) the severity of MR and 2) the presence or absence of symptoms. Studies have shown that Cardiovascular Magnetic Resonance (CMR) is an accurate method to quantify the severity of MR. However, studies have also shown that symptoms are not necessarily related to the presence of symptoms. Thus, there appears to be a disconnect between the severity of MR and symptoms. Recent analysis of our data has shown that females and older patients with smaller ventricles, lower stroke volumes, and lower regurgitant volume relative to regurgitant fraction tend to be symptomatic. These findings suggest that decreased left ventricular compliance, i.e. diastolic dysfunction, may play an important role as an etiology of symptoms in patients with mitral regurgitation. The aim of this study is to study the presence of diastolic dysfunction in patients with MR and its association with symptom burden and exercise capacity.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Pressure volume loop evaluation
- DIAGNOSTIC_TEST cardiovascular magnetic resonance imaging
- DIAGNOSTIC_TEST Cardiopulmonary exercise testing (CPET)
- DIAGNOSTIC_TEST Kansas City Cardiomyopathy Questionairre
Study Locations (1)
New Jersey
- Morristown Medical Center — Morristown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-01-02 |
| Est. Completion | 2027-05-02 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06738615
The ClinicalTrials.gov registry entry for NCT06738615 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 40 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Atlantic Health System, which has 9 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Mitral Insufficiency appearing as the primary indexed condition, and to 4 interventions — of which Pressure volume loop evaluation is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06738615 reports 1 study location spanning 1 distinct geographic area — top geographies include New Jersey. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06738615 about?
NCT06738615 is a clinical study titled "Assessing the Relationship Between Symptoms and Mitral Regurgitnant. Severity". The current American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend surgery in patient with mitral regurgitation (MR) based on 1) the severity of MR and 2) the presence or absence of symptoms. Studies have shown that Cardiovascular Magnetic Resonance (CMR) is an accu...
What is the current status of trial NCT06738615?
This trial is currently recruiting. The enrollment target is 40 participants. The study started on 2025-01-02. Estimated completion is 2027-05-02.
What conditions does trial NCT06738615 study?
This clinical trial studies the following conditions: Mitral Insufficiency. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06738615?
The interventions under investigation include: Pressure volume loop evaluation (DIAGNOSTIC_TEST), cardiovascular magnetic resonance imaging (DIAGNOSTIC_TEST), Cardiopulmonary exercise testing (CPET) (DIAGNOSTIC_TEST), Kansas City Cardiomyopathy Questionairre (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06738615?
This trial is sponsored by Atlantic Health System, which has 9 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06738615 being conducted?
This trial has 1 study location across New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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