Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

NCT06726148 · View on ClinicalTrials.gov ↗

Study Summary

Phase I: Characterize safety and tolerability of ECI830 as a single agent and in combination with ribociclib and fulvestrant. Identify dose range for optimization/recommended dose for future studies. Phase II: Assess the anti-tumor activity of ECI830 in combination with ribociclib and fulvestrant in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer.

Interventions

  • DRUG ribociclib
  • DRUG fulvestrant
  • DRUG ECI830

Study Locations (20)

Other

  • Novartis Investigative Site — Brno
  • Novartis Investigative Site — Copenhagen
  • Novartis Investigative Site — Odense C
  • Novartis Investigative Site — Bordeaux
  • Novartis Investigative Site — Saint-Herblain
  • Novartis Investigative Site — Heidelberg
  • Novartis Investigative Site — Ulm

Victoria

  • Novartis Investigative Site — Clayton
  • Novartis Investigative Site — Melbourne

California

  • University of California LA — Los Angeles

Florida

  • Florida Cancer Specialists — Fort Myers

Massachusetts

  • Dana Farber Cancer Institute — Boston

Missouri

  • WA Uni School Of Med — St Louis

New York

  • Memorial Sloan Kettering — New York

Tennessee

  • SCRI Oncology Partners — Nashville

Trial Details

FieldValue
Enrollment Target 280 participants
Start Date 2025-04-03
Est. Completion 2028-09-25
Phase Phase 1

Sponsor

Novartis Pharmaceuticals

792 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06726148

The ClinicalTrials.gov registry entry for NCT06726148 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 280 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novartis Pharmaceuticals, which has 792 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Advanced HR+/HER2- Breast Cancer appearing as the primary indexed condition, and to 3 interventions — of which ribociclib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06726148 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Other, Victoria, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06726148 about?

NCT06726148 is a clinical study titled "Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and Other Advanced Solid Tumors". Phase I: Characterize safety and tolerability of ECI830 as a single agent and in combination with ribociclib and fulvestrant. Identify dose range for optimization/recommended dose for future studies. Phase II: Assess the anti-tumor activity of ECI830 in combination with ribociclib and fulvestrant i...

What is the current status of trial NCT06726148?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 280 participants. The study started on 2025-04-03. Estimated completion is 2028-09-25.

What conditions does trial NCT06726148 study?

This clinical trial studies the following conditions: Advanced HR+/HER2- Breast Cancer, Advanced CCNE1-amplified Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06726148?

The interventions under investigation include: ribociclib (DRUG), fulvestrant (DRUG), ECI830 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06726148?

This trial is sponsored by Novartis Pharmaceuticals, which has 792 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06726148 being conducted?

This trial has 20 study locations across California, Florida, Massachusetts, Missouri, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial