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NCT06723743 · ClinicalTrials.gov registry record · NA

Transcutaneous Vagus Nerve Stimulation for Attention and Memory

A NA study of Traumatic Brain Injury (TBI) Patients, sponsored by Baylor College of Medicine.

Recruiting
Registry status
NA
Development phase
30
Enrollment target
2
Study locations

NCT06723743: Recruiting NA study of Traumatic Brain Injury (TBI) Patients, sponsored by Baylor College of Medicine.

NCT06723743 is a NA study of Traumatic Brain Injury (TBI) Patients that is actively recruiting participants, run by Baylor College of Medicine. The registered enrollment target is 30 participants, below the 188-participant average among 4 other Traumatic Brain Injury (TBI) Patients trials with a reported enrollment target (84% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06723743, a NA study of Traumatic Brain Injury (TBI) Patients, is actively recruiting participants, sponsored by Baylor College of Medicine.

RECRUITING
Registry status
NA
Development phase
30 participants
Enrollment target
2
Study locations

Study Summary

This clinical trial aims to evaluate whether transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive brain stimulation method, can improve attention and memory in veterans with traumatic brain injury (TBI) and depression and/or posttraumatic stress disorder (PTSD). The study seeks to answer two main questions: 1. Can active taVNS improve attention and memory compared to sham (placebo) stimulation? 2. Does taVNS affect heart rate variability (HRV)? taVNS delivers a gentle electrical current to the vagus nerve through electrodes placed on the ear, targeting brain areas involved in attention and memory without requiring surgery. This study uses a crossover design, meaning all participants will experience two sessions: one with active taVNS and one with sham stimulation. The sham session feels similar but does not deliver actual stimulation, allowing researchers to compare the two and understand taVNS's effects on the brain. In a single visit, participants will: * Complete eligibility screening (questionnaires and vital signs). * Undergo two sessions (one active and one sham), randomly assigned. * Perform attention tasks before and after each session. * Have their heart rate monitored during the sessions. The findings will help determine whether taVNS could be an effective treatment for improving attention and memory in veterans with TBI.

Primary Outcome

Aim 1: To evaluate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on sustained attention and working memory. Attention and memory performance will be assessed using the Gradual Onset Continuous Performance Task (gradCPT), a validated computerized test that measures the ability to sustain attention and respond selectively to relevant stimuli. This cognitive test measures sustained attention and inhibitory control. During the test, subjects view a continuous stream of gra

Conditions Studied

Traumatic Brain Injury (TBI) Patients

Interventions

  • OTHER Transcutaneous vagus nerve stimulation for attention in veterans with TBI
  • DEVICE Soterix Medical Vagus Nerve Stimulation mini-CT

Study Locations (2)

Texas

  • Michael E. DeBakey VA Medical Center - Houston
  • Michael E. DeBakey VA Medical Center - Houston

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2025-11
Est. Completion 2026-02
Phase NA
Baylor College of Medicine

616 total trials

What NCT06723743 shows while recruiting

NCT06723743 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 188-participant average among 4 other Traumatic Brain Injury (TBI) Patients trials with a reported enrollment target (84% lower).

The record links to 1 condition, with Traumatic Brain Injury (TBI) Patients appearing as the primary indexed condition, and to 2 interventions - of which Transcutaneous vagus nerve stimulation for attention in veterans with TBI is the first listed.

NCT06723743 reports a single indexed study location in Texas.

Frequently Asked Questions

What is clinical trial NCT06723743 about?

NCT06723743 is a clinical study titled "Transcutaneous Vagus Nerve Stimulation for Attention and Memory". This clinical trial aims to evaluate whether transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive brain stimulation method, can improve attention and memory in veterans with traumatic brain injury (TBI) and depression and/or posttraumatic stress disorder (PTSD). The study seeks t...

What is the current status of trial NCT06723743?

This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2025-11. Estimated completion is 2026-02.

What conditions does trial NCT06723743 study?

This clinical trial studies the following conditions: Traumatic Brain Injury (TBI) Patients.

What interventions are being tested in trial NCT06723743?

The interventions under investigation include: Transcutaneous vagus nerve stimulation for attention in veterans with TBI (OTHER), Soterix Medical Vagus Nerve Stimulation mini-CT (DEVICE).

Who is sponsoring clinical trial NCT06723743?

This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06723743 being conducted?

This trial has 2 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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More recruiting context for NCT06723743

Source: ClinicalTrials.gov NCT06723743, the US trial registry maintained by the National Library of Medicine. NCT06723743 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.