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A Double-blind Dual Study Assessing Safety and Efficacy of Buntanetap in Participants With Early AD
NCT06709014 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this clinical trial is to learn if buntanetap/Posiphen works to treat early Alzheimer's disease in adults aged 55-85. It will also learn about the safety of buntanetap/Posiphen. The main questions it aims to answer are: * Does buntanetap/Posiphen improve cognition as measured by ADAS-Cog13? * Does buntanetap/Posiphen improve function as measured by ADCS-iADL? * What medical issues do participants have, if any, when taking buntanetap/Posiphen? Researchers will compare buntanetap/Posiphen to a placebo (a look-alike substance that contains no drug) to see if buntanetap/Posiphen works to treat early Alzheimer's disease. Participants will: * Take buntanetap/Posiphen or a placebo every day for 18 months * Visit the clinic periodically for checkups, tests, and questionnaires (screening visits, enrollment, month 1, month 3, month 6, month 9, month 12, month 15, month 18), including a volumetric MRI at month 6 and month 18 * Complete pre- and post-clinic visit phone calls
Conditions Studied
Interventions
- DRUG Placebo
- DRUG buntanetap/posiphen
Study Locations (20)
California
- Advanced Research Center — Anaheim
- Hope Clinical Research — Canoga Park
- Eximia Clinical Research — Encino
- Sun Valley Research — Imperial
- Mary S. Easton Center for Alzheimer's Research and Care, UCLA — Los Angeles
- UC Davis Alzheimer's Disease Research Center — Sacramento
- The Neuron Clinic — San Marcos
Florida
- Visionary Investigators Network — Aventura
- SFM Clinical Research — Boca Raton
- K2 Medical Research — Clermont
- K2 Medical Research Daytona — Daytona Beach
- Neuropsychiatric Research Center — Fort Myers
- Velocity Clinical — Hallandale
- Jacksonville Center for Clinical Research — Jacksonville
Arizona
- MD First Research — Chandler
- Xenoscience — Phoenix
- Clinical Endpoints — Scottsdale
Colorado
- Mountain Neurological Center — Basalt
- CenExel Rocky Mountain — Englewood
Connecticut
- Research Center for Clinical Trials — Norwalk
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 760 participants |
| Start Date | 2025-02-04 |
| Est. Completion | 2028-06 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06709014
The ClinicalTrials.gov registry entry for NCT06709014 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 760 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Annovis Bio, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Early Alzheimers Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06709014 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Florida, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06709014 about?
NCT06709014 is a clinical study titled "A Double-blind Dual Study Assessing Safety and Efficacy of Buntanetap in Participants With Early AD". The goal of this clinical trial is to learn if buntanetap/Posiphen works to treat early Alzheimer's disease in adults aged 55-85. It will also learn about the safety of buntanetap/Posiphen. The main questions it aims to answer are: * Does buntanetap/Posiphen improve cognition as measured by ADAS-Co...
What is the current status of trial NCT06709014?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 760 participants. The study started on 2025-02-04. Estimated completion is 2028-06.
What conditions does trial NCT06709014 study?
This clinical trial studies the following conditions: Early Alzheimers Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06709014?
The interventions under investigation include: Placebo (DRUG), buntanetap/posiphen (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06709014?
This trial is sponsored by Annovis Bio, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06709014 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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