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ACTIVE NOT RECRUITING Phase 3

A Study to Investigate Improvement in Pruritus of Lichen Simplex Chronicus With Dupilumab Injections Compared With Placebo in Male and Female Participants Aged at Least 18 Years (STYLE 2)

NCT06687980 · View on ClinicalTrials.gov ↗

Study Summary

This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged at least 18 years with LSC. Study details include: The study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The follow-up duration after treatment will be 12 weeks. The number of visits will be 6.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Dupilumab

Study Locations (20)

Other

  • Investigational Site Number : 0320201 — Buenos Aires
  • Investigational Site Number : 0320203 — Córdoba
  • Investigational Site Number : 0560202 — Alken
  • Investigational Site Number : 0560203 — Maldegem

Texas

  • Bellaire Dermatology Associates,- Site Number : 8400202 — Bellaire
  • Austin Institute for Clinical Research - Pflugerville- Site Number : 8400203 — Pflugerville
  • Progressive Clinical Research - San Antonio- Site Number : 8400206 — San Antonio

California

  • Cosmetic Dermatology of Orange County- Site Number : 8400232 — Anaheim
  • Center for Dermatology Clinical Research- Site Number : 8400226 — Fremont

Florida

  • University of Miami Miller School of Medicine- Site Number : 8400218 — Miami
  • TrueBlue Clinical Research- Site Number : 8400208 — Tampa

Alberta

  • Investigational Site Number : 1240210 — Calgary
  • Investigational Site Number : 1240207 — Edmonton

Georgia

  • Skin Care Physicians of Georgia - Macon- Site Number : 8400236 — Macon

Indiana

  • Southern Indiana Clinical Research Center- Site Number : 8400230 — Columbus

Kentucky

  • Equity Medical - Bowling Green- Site Number : 8400240 — Bowling Green

Trial Details

FieldValue
Enrollment Target 138 participants
Start Date 2024-11-25
Est. Completion 2026-08-31
Phase Phase 3

Sponsor

Sanofi

275 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06687980

The ClinicalTrials.gov registry entry for NCT06687980 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 138 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Sanofi, which has 275 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Lichen Simplex Chronicus appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06687980 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Other, Texas, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06687980 about?

NCT06687980 is a clinical study titled "A Study to Investigate Improvement in Pruritus of Lichen Simplex Chronicus With Dupilumab Injections Compared With Placebo in Male and Female Participants Aged at Least 18 Years (STYLE 2)". This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous injections compared with placebo injections in male and female participants aged at least 18 years with LSC. Study details include: The study duration...

What is the current status of trial NCT06687980?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 138 participants. The study started on 2024-11-25. Estimated completion is 2026-08-31.

What conditions does trial NCT06687980 study?

This clinical trial studies the following conditions: Lichen Simplex Chronicus. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06687980?

The interventions under investigation include: Placebo (DRUG), Dupilumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06687980?

This trial is sponsored by Sanofi, which has 275 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06687980 being conducted?

This trial has 20 study locations across California, Florida, Georgia, Indiana, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial