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NCT06682442 · ClinicalTrials.gov registry record · NA
Induction Chemotherapy Response-Guided Radiation for EBV-Associated Nasopharyngeal Carcinoma
A NA study of Nasopharyngeal Carcinoma and Nasopharyngeal Cancer, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- NA
- Development phase
- 66
- Enrollment target
- 1
- Study location
NCT06682442: Recruiting NA study of Nasopharyngeal Carcinoma and Nasopharyngeal Cancer, sponsored by University of California, San Francisco.
NCT06682442 is a NA study of Nasopharyngeal Carcinoma and Nasopharyngeal Cancer that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 66 participants, below the 90-participant average among 7 other Nasopharyngeal Carcinoma trials with a reported enrollment target (27% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06682442, a NA study of Nasopharyngeal Carcinoma and Nasopharyngeal Cancer, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- NA
- Development phase
- 66 participants
- Enrollment target
- 1
- Study location
Study Summary
This clinical trial tests the effect of induction chemotherapy response-guided radiation (de-escalated intensity-modulated radiation therapy \[IMRT\]) compared to standard IMRT in patients with Epstein-Barr virus (EBV)-associated nasopharyngeal cancer. Intensity-modulated radiation therapy (IMRT) is an advanced form of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. Thin beams of radiation of different intensities are aimed at the tumor from many angles. This type of radiation therapy reduces the damage to healthy tissue near the tumor. Radiation therapy sometimes causes unwanted symptoms or side effects, including late effects such as hearing loss and dental problems. The severity of the side effects is related to the radiation dose received and the amount of tissue that received radiation. De-escalation IMRT uses lower doses of radiation based on a good response to induction chemotherapy. Giving de-escalated IMRT may be as effective as standard doses of IMRT in treating patients with EBV-associated nasopharyngeal cancer.
Primary Outcome
PFS is defined as the proportion of participants alive without progression of disease from the first day of radiotherapy to progression or death by any cause, whichever occurs first, assessed up to 2 years after the last day of radiation therapy. The Kaplan-Meier method will be used to estimate the PFS rate along with a 90% confidence interval.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- RADIATION Intensity-Modulated Radiation Therapy (IMRT)
- PROCEDURE Radiographic Imaging
Study Locations (1)
California
- University of California, San Francisco - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2025-03-18 |
| Est. Completion | 2032-03-31 |
| Phase | NA |
What NCT06682442 shows while recruiting
NCT06682442 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, below the 90-participant average among 7 other Nasopharyngeal Carcinoma trials with a reported enrollment target (27% lower).
The record links to 5 conditions, with Nasopharyngeal Carcinoma appearing as the primary indexed condition, and to 3 interventions - of which Biospecimen Collection is the first listed.
NCT06682442 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06682442 about?
NCT06682442 is a clinical study titled "Induction Chemotherapy Response-Guided Radiation for EBV-Associated Nasopharyngeal Carcinoma". This clinical trial tests the effect of induction chemotherapy response-guided radiation (de-escalated intensity-modulated radiation therapy \[IMRT\]) compared to standard IMRT in patients with Epstein-Barr virus (EBV)-associated nasopharyngeal cancer. Intensity-modulated radiation therapy (IMRT) is...
What is the current status of trial NCT06682442?
This trial is currently recruiting. It is a NA study. The enrollment target is 66 participants. The study started on 2025-03-18. Estimated completion is 2032-03-31.
What conditions does trial NCT06682442 study?
This clinical trial studies the following conditions: Nasopharyngeal Carcinoma, Nasopharyngeal Cancer, Stage III Nasopharyngeal Carcinoma AJCC v8, Stage IVA Nasopharyngeal Carcinoma AJCC v8, Nasopharyngeal Cancer Stage.
What interventions are being tested in trial NCT06682442?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Intensity-Modulated Radiation Therapy (IMRT) (RADIATION), Radiographic Imaging (PROCEDURE).
Who is sponsoring clinical trial NCT06682442?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06682442 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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